Sr. Scientist II, Research Production Core

Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by DesignTM platform for CRISPR-based genetic medicine. 

We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for a Sr. Scientist II to join our team and advance our platform. The candidate should have a passion for working collaboratively with biologists and bioengineers to enable building the necessary tools for meeting the new frontier of CRISPR-based therapeutics. Additionally, the candidate would have hands-on experience of vector production. and strong organizational skills. 

The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities. 

Key Responsibilities: 

• Direct high-throughput production screening of research grade viral vectors (AAV and LV) from upstream cell culture, downstream purification, QC testing, and assay development to drive Discovery activities and delivery of Scribe's Cas nucleases for therapeutic pipeline programs
• This position involves 20% office-based and 80% laboratory-based work, coordinating with internal teams and external CROs for vector production, while supporting development activities across multiple early-stage programs
• Manage routine upstream cell culture and vector production, as well as downstream purification operations to produce viral vectors 
• Motivated to learn new modalities to support the various delivery options for gene editing therapeutics (including mRNA and LNP technologies)
• Candidate should have prior knowledge in analytical method development to act as a scientific liaison for CMC assay development support of early-stage programs
• Excellent communication and presentation skills, capable of conveying complex technical information and experimental results and plans in a clear, concise, and influential manner to relevant cross-functional teams 
•  Must be a team player, strong critical thinker, exhibit a willingness to meet project timelines and multitask effectively in a dynamic fast-paced environment under challenging timelines
• Develop procedures and documentation to successfully perform specific unit operations in the production of viral vectors. 
• Maintain operations and personnel scheduling, oversee vector lab organization, inventory, and equipment maintenance, and fulfill other required duties for continuous production operations
• Maintain scientific and technical expertise of self and team through familiarity with scientific literature and developing relationships with thought leaders
• Seeking a team player with strong critical thinking skills, capable of meeting project timelines, multitasking effectively while fostering a driven, collaborative, and fun atmosphere for rigorous scientific work
• Responsibilities include managing one or more Research Associates

Required Skills and Background: 

• MS with 10+ years of relevant experience, or BS with 12+ years of relevant experience in biochemistry, bioengineering, chemical engineering, virology, or related field in an academic or industry lab 
• Solid proficiency in common biochemical and molecular biology techniques like PCR (ddPCR preferred), ELISA, SDS-PAGE, Agarose Gels, UV-Vis spectroscopy, activity assays
• Proficiency in advanced analytical techniques like HPLC: SEC, RP-HPLC and ion-exchange and DLS, CE 
• Excellent verbal and written communication skills and ability to handle multiple tasks while meeting timelines and adapting to changing priorities. 
• Strong organizational skills, high attention to details, and ability to work in a collaborative environment 

Preferred Skills and Background: 

• Familiarity with CRISPR technologies 
• Prior experience working in or leading a Vector Core or process development  
• mRNA production and chromatography 
• Ability to communicate at all levels and across various functions
• Prior people management experience
• Experience with JMP and DoE, Empower/Chemstation, Unicorn, and SoftMax Pro software  

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com. 

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status. 

At the time of posting, the base pay wage range for this role is $140,000-185,000 per year.  The offered pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications, training, and market data.  Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.