Technical Development Senior Scientist

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech, a member of the Roche Group.

The Opportunity

RMG, in the Cell Culture and Bioprocess Operations department, is responsible for providing support to pre-Early Stage Research to Early Development projects with high-throughput protein production from mammalian transient cultures. We are looking for a motivated candidate with cell culture and sterile technique experience to join our team to enable protein production at Genentech and help advance our portfolio. 

Key Responsibilities

• Perform transient transfections in CHO and HEK293 cells in scales 1mL to 25L to support pipeline productions adhering to established protocols

• Maintain seed train cell cultures in bioreactors and shake flasks

• Operate liquid handlers - Tecan and Hamilton for automated processes

• Operate wave bag reactors for productions and cell maintenance

• Maintain and troubleshoot key cell culture instruments such as Vi-Cell, Nova Flex2, Nova Flex, Cedex and bioreactors

• Participate in troubleshooting production or platform processes

• Participate in lab management and data management. 

• Lead development and technology projects to improve existing cell culture platforms and develop new platforms to deliver diverse protein and cellular reagents to enable a large number of research programs, providing both technical oversight and strategic guidance to other team members.

• Author and review protocols, technical reports, and scientific articles

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Who you are

The candidate must be highly self-motivated, organized, detail oriented and responsive to feedback. The candidate is expected to precisely follow written procedures, practice sterile technique, demonstrate accurate documentation skills, and report deviations in a timely manner. They should be able to work independently within guidelines and policies, with minimal guidance. 

Qualifications

Required:

• PhD (with 0-2yrs relevant experience) in Biotechnology, Chemistry, Biochemistry or related fields

• Suspension adapted mammalian cell culture (CHO and/or HEK293)

• Excellent written and verbal communication skills, and have strong collaborative skills.

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Preferred:

• State-of-the-art transient and stable protein expression experience

• Relevant bioreactor experience

• Hands-on experience with automation and liquid handlers like Tecan Freedom Evo and Hamilton Microlab Star

• Knowledge of cell biology, cell engineering, molecular biology, recombinant protein purification and protein characterization is preferred

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of South San Francisco, CA is $95,400 to $177,200. Annual Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.