Translational Co-op

Company Summary: 

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first re-dosable and targetable DNA medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.

Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

Ring Therapeutics is seeking a Co-op to join the Translation team to help validate a new gene therapy in vivo. This co-op will run from January 10 - June 28. The successful candidate will work with a scientific mentor to gain direct, hands-on experience in developing and conducting analytical assays to validate viral vectors in rodent models. Lab-based techniques learned can include nucleic acid isolation from rodent tissues, molecular assays like qPCR, RT-PCR, ddPCR, protein-based assays like Western Blot and ELISA, Cell and tissue culture, etc. This will be a great opportunity to participate in cutting-edge virology, viral vector engineering, and synthetic biology research. We are searching for enthusiastic and highly motivated individuals who are comfortable multitasking and working both with a team and independently while gaining valuable career experience in translational science.

Key Responsibilities:

• Study the molecular biology of novel human and/or animal viruses.
  Participate in the execution of immunological assays to assess vector transduction.
• Culture, maintain and characterize mammalian cell lines.
• Participate in the development of IHC/IF staining, imaging, collection, and image analysis.
• Maintain electronic lab notebooks and communicate results to the scientific team.
  Work independently and collaborate with scientific colleagues in support of team goals.
  Adhere to laboratory safety requirements and procedures.
• Maintain scientific curiosity and familiarity with relevant literature.

Requirements :

• Candidates must be currently enrolled in a minimum of a master’s degree program in Biotechnology or Bioengineering or cell and molecular biology program.
• Experience with aseptic techniques, mammalian cell culture and histology are a plus.
• Ability to work closely with a small team as well as independently with supervision.
• Desire to work in an innovative and collaborative environment.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect theret