Translational Reseach Scientist I/II
Job Description
We make healthy cells invisible to targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells displaying the target protein and are then vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.
What we value in our fellow Voracians
Passion:Â Enthusiastically driving our science toward innovative medicines
Fellowship:Â Fostering genuine bonds of collaboration and mentorship
Humility:Â Acting selflessly by putting the collective mission first
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Who we are looking for:
Vor Bio is seeking a highly motivated scientist to join the Pre-Clinical and Translational Biology (PTB) team. The Translational Research Scientist will lead clinical assay development and perform data analysis. This is a full-time position onsite and will report to the Associate Director of Translational Biology.Â
Key areas of responsibilities:
- Perform routine wet-lab sample processing and analysis of clinical samples employing cell biology, molecular biology, flow-based, and LBA assays.
- Participate in designing experiments, executing, data interpretation, and leading troubleshooting.
- Lead the clinical assay development/ validation/ qualification to appropriate regulatory standards and ensure the readiness of assays for clinical testing.
- Reiew data generated by the 3rd party labs, perform QC checks of lab reports and resolve data quality or reporting issues with the vendor.Â
- Performs data analysis and prepares figures for data presentations at meetings.Â
- Effectively provide day-to-day vendor oversight and ensures quality translational data generation by 3rd party labs. Proactively identify issues, implement solutions, and escalate, if necessary, to appropriate internal stakeholders.Â
- Work in collaboration with the Clinical team for Translational-related activities.
- Assist with the selection and contracting of specialty labs and biobanking facilities.Â
- Assist with developing content for abstracts, posters, manuscripts, and regulatory submissions.Â
- Participates in drafting SOPs, working instructions, test methods, study protocols, and technical reports.
Skills and requirements:Â
- Ph.D. in life science with 1-2 years of relevant work experienceÂ
- Wet-lab experience is required. Experience with flow cytometry and LBA assays are a must. Experience with molecular assays and gene sequencing data is a plus.Â
- Basic knowledge of the drug development process and translational research is a plus.
- Detail-oriented, critical thinker, analytical, organized, great communication skills, and strong troubleshooting and problem-solving ability
- Ability to work independently but within a highly cross-functional environment
- Must be adaptable, accountable, enthusiastic, and have a strong work ethics Â
By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
In an effort to protect our coworkers and communities from COVID-19, where permitted by law Vor Biopharma Inc. requires all employees to be fully vaccinated against COVID-19 and up to date with their vaccination unless they receive an approved reasonable accommodation for medical or religious reasons.
Please visit our website at https://www.vorbio.com/ for more information.
Date Posted
07/20/2023
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5
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