Tech Jobs in St. Louis, MO

61,334 open positions · Updated daily

St. Louis is becoming a tech hub thanks to a blend of healthcare innovation, a strong manufacturing base, and a growing fintech scene. With 14,708 tech openings, the city offers a mix of high‑growth startups and established firms, all powered by a talent pool fed by universities such as Saint Louis University and Washington University.

Key sectors driving the market include healthtech—home to life‑science giants like BJC HealthCare and Eli Lilly—financial technology, logistics software, and data analytics. Companies like Enterprise Holdings, Vontel, and the City of St. Louis use cutting‑edge platforms to streamline operations, while startups in the Central West End and Midtown districts are hiring full‑stack developers, AI/ML engineers, and cybersecurity specialists.

While the cost of living in St. Louis remains 15% below the national average, median rent for a one‑bedroom apartment in Midtown is around $1,200 and the median home price sits near $225,000. Transparent salary listings let candidates evaluate whether a role’s pay aligns with local living expenses—ensuring you can afford the lifestyle you want without hidden surprises.

Provider Architect - R01544706

Company: Brillio

Location: St. Louis, MO

Posted Jan 28, 2025

Brillio is a leading digital technology service provider, known for its world-class professionals and commitment to client satisfaction. The company is seeking an experienced Provider Architect with expertise in cloud-native application development, Neo4j Graph DB, REST APIs, Spark, and Medallion Architecture. The role involves designing and implementing scalable, secure solutions within the healthcare provider domain, collaborating with cross-functional teams, and mentoring team members.

Banking Partnership Response Manager

Company: Cash App

Location: St. Louis, MO

Posted Jan 29, 2025

Block is seeking a Banking Partnership Response Manager with 7+ years of experience in regulatory compliance or risk management in the financial services industry. The role involves working closely with senior leaders and external partners to ensure successful implementation of regulatory compliance and operational risk initiatives. The candidate will be responsible for managing workstreams, ensuring enterprise-wide compliance, and dealing with ambiguity in a fast-paced environment. The ideal candidate should have a strong understanding of US Consumer Financial Protection Laws, Dodd-Frank Act, Financial Crimes, US AntiMoney Laundering, and USA PATRIOT Act. They should also possess excellent communication, collaboration, and presentation skills, and be able to thrive in a remote environment.

Insurance Verification Specialist (ON SITE)

Company: Blink Health

Location: St. Louis, MO

Posted Jan 28, 2025

Blink Health is a rapidly growing healthcare technology company that aims to make prescriptions more accessible and affordable. Their primary products, BlinkRx and Quick Save, streamline the prescription supply chain, improving patient access to medications and health outcomes. BlinkRx is a unique platform offering transparent pricing, free home delivery, and excellent support for branded medications. The company values collaboration and innovation, providing growth opportunities and the chance to revolutionize pharmacy care. They offer competitive benefits, including health insurance, 401k, holiday pay, overtime, and a casual dress code.

Senior Analyst, General Accounting (Hybrid)

Company: Protective Life

Location: St. Louis, MO

Posted Jan 29, 2025

The job description outlines responsibilities for an Accounting team member, including managing accounting for various product lines, preparing journal entries, accruals, and reconciliations, supporting month-end close process, and assisting in audits. The role requires an Accounting degree, strong computer skills, and insurance knowledge. The salary range is $75,000 to $110,000 with additional incentive opportunities.

Frequently Asked Questions

What types of tech jobs are available in St. Louis, MO?
St. Louis offers roles from software engineering and data science to cybersecurity, DevOps, UI/UX design, AI/ML research, and product management. The city’s healthtech and fintech sectors demand specialists in electronic health records, blockchain, and regulatory tech, while logistics firms need supply‑chain analytics and IoT developers.
How do remote and on‑site trends look in St. Louis?
Many companies now support hybrid models, with on‑site work preferred for roles that require collaboration, such as product design or systems engineering. Pure remote positions are common in software development and data analysis. Companies like Enterprise and Vontel offer flexible schedules, but a 3‑day on‑site requirement is typical for senior engineering roles.
Who are the major employers in St. Louis?
Key employers include BJC HealthCare, Enterprise Holdings, Eli Lilly & Co., Vontel, City of St. Louis, and the St. Louis Science Center’s research labs. Additionally, the city’s startup ecosystem includes companies such as Glean, Tasty, and the Midtown tech incubator, all actively hiring tech talent.
What are salary expectations for tech roles in St. Louis?
Median base salary for software engineers in St. Louis is around $95,000, with senior roles reaching $120,000+. Data scientists average $98,000, while cybersecurity analysts earn $88,000. These figures exceed the national average for comparable roles, reflecting the city’s focus on high‑growth industries. Transparent listings on Job Transparency help you benchmark offers against local market rates.
What advice is there for relocating to St. Louis for tech work?
Plan your move by researching neighborhoods: Midtown and the Central West End offer vibrant tech scenes and affordable housing; the St. Louis Riverfront and Oakville provide quieter options with easy access to downtown. Use Job Transparency’s salary tool to confirm that offers cover living costs. When interviewing, ask about relocation packages, housing stipends, and the company’s remote policy. Finally, tap local networking groups such as the St. Louis Tech Council and meetups to accelerate integration.

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