Job Description
GRAIL is seeking a Senior Data Scientist to join the Machine Learning team within the Computational Biology and Machine Learning (CBML) group. In this role you will work at the intersection of machine learning genomics and clinical science to advance early cancer detection. You will collaborate closely with scientists engineers and clinicians to identify novel biological signals improve classification performance and develop innovative approaches for cancer detection and categorization using GRAIL’s rich sequencing datasets.
This is a highly impactful role where you will apply state-of-the-art machine learning techniques—including modern AI approaches—to real-world clinical challenges. Your work will directly contribute to scientific discoveries peer-reviewed publications and the development of transformative products for early cancer detection.
This is a hybrid role based in Menlo Park CA (moving to Sunnyvale CA in Fall 2026). Our current flexible work arrangement policy requires that a minimum of 40% or 16 hours of your total work week be on-site. Your specific schedule determined in collaboration with your manager will align with team and business needs and could exceed the 40% requirement for the site.
Responsibilities:
Envision design and lead projects to evaluate and improve machine learning classifier performance for cancer detection
Collaborate cross-functionally with scientists engineers and clinicians to plan execute and interpret experiments
Develop high-quality reproducible and scalable software aligned with sound engineering principles
Apply best practices in machine learning and statistics to generate robust interpretable and reliable results
Analyze large-scale sequencing and genomics datasets to extract meaningful biological insights
Contribute to the development and evaluation of novel machine learning methods including deep learning approaches
Communicate findings and present updates regularly in technical and cross-functional forums
Contribute to scientific publications internal tools and production systems
These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion.
Required Qualifications
Ph.D. in Bioinformatics Computational Biology Computer Science Statistics Machine Learning or a related field with 2+ years of relevant experience OR
M.S. with 4+ years of relevant experience OR
B.S. with 6+ years of relevant experience or equivalent practical experience2+ years of experience applying machine learning or statistical modeling in a research or production environment
Strong expertise in data analysis using Python or R
Deep understanding of modern machine learning and statistical methods
Experience developing reproducible well-structured code in a collaborative environment
Strong written and verbal communication skills
Preferred Qualifications:
Experience with modern AI techniques including deep learning and/or large language model (LLM) training or adaptation
Experience working with sequencing or genomics data and deriving biological insights
Track record of scientific contributions (e.g. publications tools datasets patents or conference presentations)
Experience with system-level programming languages (e.g. Go Java C C++)
Familiarity with version control (e.g. Git) and reproducible research practices in Linux environments
Demonstrated ability to independently drive projects while collaborating effectively across teams
Interest in translating research innovations into production-ready systems
Top Skills
What the Team is Saying




What We Do
GRAIL is a healthcare company whose mission is to detect cancer early when it can be cured. GRAIL is using the power of high-intensity sequencing population-scale clinical studies and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology and to develop and commercialize pioneering products.
Why Work With Us
Everything we do is guided by our mission to detect cancer early when it can be cured. It’s the reason we’re here and it’s no small task. The right people make all the difference. That’s why we’re looking for those who strive to share their knowledge contribute their skills inspire each other and commit to something bigger than themselves.
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GRAIL Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
GRAIL has a variety of work types depending on the roles. Some are onsite like a lab role others are hybrid and still others are remote. Hybrid is typically Tuesday and Thursday but leaders may be flexible depending on the role.
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Date Posted
04/05/2026
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