Job Description
Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time actionable insights to physicians providing critical information about the right treatments for the right patients at the right time.
The Role
As a Senior Software Engineer II on the Data Products team you will act as a technical leader in building the foundational infrastructure that powers Tempus’ clinical research and AI capabilities. The Data Products team provides a platform that supports the full lifecycle of data — from the secure ingestion of data to the cataloging and analysis of that data powering complex algorithms and models.
You will play a pivotal role in architecting and driving technical strategy for services and APIs that allow bioinformatics scientists ML and Agent developers to rapidly develop deploy and operate their solutions in a highly regulated secure and scalable environment. You will focus on data storage and governance containerized compute orchestration and forging new connections with the latest GenAI technologies to ensure our platform remains a robust foundation for cutting-edge technologies that help patients live longer healthier lives.
Responsibilities• Lead Technical Architecture: Drive the high-level design and architecture of distributed systems at scale ensuring alignment with strategic goals for Tempus’s data management platform.
• System Design & Implementation: Design implement and test complex production backend web services in TypeScript serving as a standard-bearer for code quality and system reliability.
• Data Pipelining: Build and maintain pipelines to load schema-defined data into the data warehouse using cloud storage and data warehousing technologies. Provision access to this data according to Tempus’s internal policies and regulatory obligations.
• Stakeholder & Product Leadership: Use exemplary stakeholder management skills to work closely with Product Managers to translate complex business requirements into technical roadmaps ensuring clear communication and alignment with business goals.
• Operational Excellence: Take operational responsibility for platform systems in production including on-call duties. You will not only troubleshoot complex technical issues but also proactively monitor systems to ensure reliability and performance optimization.
• Mentorship & Best Practices: Mentor other engineers on your team fostering a culture of continuous learning. Along with your Engineering Lead you will be responsible for defining and promoting best practices for software engineering including testing strategies documentation and code reviews.
• Support & Enablement: Leverage your expertise to support cross-functional science ML and AI teams. You will act as a high-level escalation point to answer user questions and resolve development or production issues regarding data and compute workflows.
Qualifications• Experience: 8+ years of experience in software or data engineering with a strong focus on platform engineering distributed data systems or backend web services.
• Education: Bachelor's or Master's degree in Computer Science Engineering or a related field or equivalent industry experience.
• Language Proficiency: Demonstrated success in writing production backend services in JavaScript/TypeScript Python or other similar languages with a willingness to work primarily in a Node.js and Python environment.
• Advanced Cloud & Infrastructure Skills:
◦ Deep experience designing and running production systems on public cloud platforms (GCP preferred).
◦ Working knowledge of cloud object storage (GCS S3) ETL services (Dataflow) and data warehousing (BigQuery).
• Data & Database Expertise: Strong familiarity with distributed relational database design (GCP Cloud Spanner) and data modeling (JSON Schema Avro or similar) including schema migrations and enforcing data contracts.
• Technical Design: Proven track record of translating complex business requirements into scalable technical designs for distributed systems.
Preferred Qualifications• Cloud Ecosystem: Experience with GCP services including GKE Cloud Spanner BigQuery and Dataflow is a plus.
• DevOps Culture: Strong familiarity with CI/CD pipelines immutable data patterns and DevOps practices.
• Domain Knowledge: Experience with data cataloging data lineage or platforms supporting ML/GenAI and/or bioinformatics workflows.
#LI-BL1$150000 - $190000
This role is based in Chicago with a hybrid setting of 3 days/week
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California Colorado New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits which may include incentive compensation restricted stock units medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race religion color national origin gender sexual orientation age marital status veteran status or disability status.
Top Skills
What the Team is Saying










What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time connect patients with therapies and clinical trials and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology neurology psychiatry cardiology and beyond—transforming how care is delivered and therapies are developed. At Tempus every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
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Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy with some roles allowing for a fully remote arrangement and some roles being onsite only.











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Date Posted
04/19/2026
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