Sr Clinical Project Research Manager

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Sr Clinical Project Research Manager based in United States.

This role sits at the center of global clinical research execution, leading complex clinical trial programs from start-up through close-out in a highly regulated environment.
You will act as the primary point of contact for sponsors, ensuring seamless communication, operational alignment, and successful delivery of study milestones.
The position requires strong leadership across cross-functional teams, including clinical operations, regulatory, and project management functions.
You will oversee multiple studies simultaneously, ensuring timelines, budgets, and quality standards are consistently met.
A key part of the role involves driving observational study execution and supporting global trial operations, often within therapeutic areas such as oncology.
You will also contribute to process improvements, audit readiness, and strategic project planning, while mentoring junior project management staff.
This is a high-visibility role with direct impact on study success, patient outcomes, and broader healthcare advancement.

The Sr Clinical Project Research Manager is responsible for leading end-to-end clinical project delivery, ensuring operational excellence, regulatory compliance, and sponsor satisfaction across assigned global studies.

• Serve as primary sponsor contact for all study-related activities from start-up through close-out.
• Lead cross-functional project teams to ensure delivery of study milestones, timelines, and budgets.
• Develop and oversee operational plans including communication, monitoring, training, compliance, and project timelines.
• Coordinate investigator meetings, site engagement, and recruitment of qualified investigators.
• Supervise project management staff (APMs/PMs) and ensure accurate, timely execution of deliverables.
• Monitor project progress, budgets, and contractual milestones, ensuring alignment with sponsor expectations.
• Support protocol development, CRFs, regulatory documentation, and other key study deliverables.
• Maintain audit-ready project documentation and support sponsor or regulatory inspections.
• Lead internal and client meetings, including project updates, bid defenses, and governance reviews.
• Drive issue resolution, risk mitigation, and continuous process improvement initiatives.
• Assist in revenue tracking, invoicing, proposals, and RFP responses as required.
• Serve as a mentor and resource for junior team members across project execution activities.

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Requirements:

This role requires extensive experience in clinical trial management within a CRO or pharmaceutical research environment, with strong leadership and regulatory knowledge.

• Bachelor’s degree or equivalent experience, with at least 5+ years in clinical project management within a CRO environment.
• Proven experience managing global clinical trials, ideally including observational studies.
• Oncology experience is preferred.
• Strong knowledge of Good Clinical Practice (GCP), ICH guidelines, and regulatory requirements.
• Experience supervising project teams and mentoring junior staff.
• Ability to manage multiple complex projects simultaneously (typically 2–3 studies).
• Excellent communication, presentation, and stakeholder management skills.
• Strong problem-solving abilities with a proactive, solution-oriented mindset.
• Experience preparing or contributing to clinical protocols, consent forms, and regulatory documentation.
• Ability to manage budgets, timelines, and contract deliverables effectively.
• Comfortable working in a remote, fast-paced, and globally distributed environment.
• Willingness to travel approximately 10% as needed.

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Benefits:

• Remote-first work environment with flexible work arrangements
• Competitive salary package with performance-based compensation
• 401(k) retirement plan with company match
• Comprehensive medical, dental, and vision insurance coverage
• Paid time off, paid holidays, and discretionary PTO policy
• Tuition reimbursement and professional development support
• Short-term and long-term disability coverage
• Life insurance and employee assistance programs
• Telemedicine access and wellness programs
• HSA/FSA flexible spending options
• Adoption assistance benefits
• Employee discounts and additional lifestyle support programs
• Strong focus on career growth, internal mobility, and leadership development