Scientist I, Vector Analytics

This is what you will do:

We are seeking a meticulous, detail-oriented individual to join our team as a Scientist - Vector Analytics, specializing in recombinant Adeno-Associated Virus (rAAV) products. In this role, you will play a critical role in ensuring the quality and compliance of our rAAV-based products through rigorous testing and analysis. The ideal candidate will have a strong background in molecular biology, biochemistry, or related fields, with hands-on experience in analytical procedures and methodologies. As a member of our AAV Therapeutic Development & Production team, you will be supporting the molecular assessment of our AAV vectors working closely with our R&D teams to provide in-process and final sample analytics.

You will be responsible for:

• Titering rAAV by multiple methods (ddPCR, qPCR, etc)
• Evaluation of packaged genome (electrophoresis and sequencing-based)
• Assessing overall purity (CE-SDS, qPCR, ELISA, etc)
• Sequence analysis and sample prep for NGS
• Writing reports, SOPs, and generating CoAs. Accurate and detailed documentation of sample records is critical using systems such as electronic lab notebooks.
• General laboratory operations - Maintaining inventories, monitoring/calibrating/cleaning equipment and checking stocks of required consumables.
• Sharing data/results in group settings and larger organizational meetings
• Evaluating new methodologies and staying well-versed with cutting edge methods

You will need to have:

• Bachelor or above in Biology or related science discipline (at least 2 years with Bachelor or 0-1 year with Masters)
• Proficient with standard AAV analytical assays: ddPCR, qPCR, DNA content assessment, ce-SDS, ELISA, etc.
• Experience with sample prep for NGS and/or an aptitude for general sequence analysis
• Excellent research task oversight skills including adherence to procedures, best practices and detailed documentation/record keeping
• Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently under pressure
• Excellent oral and written communication skills
• Demonstrated ability to utilize standard office software (Excel, PowerPoint, Word, etc.) or other Project Management/eNotebooks software
• The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

• NGS analysis skills
• Experience with cell potency assay development and evaluation
• Experience with analytics relating to plasmid DNA quality

In-person statement for 4 days in the office:

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Date Posted

05-Mar-2024

Closing Date

04-Mar-2024Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact [email protected]. Alexion participates in E-Verify.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.