Jobs at Click Therapeutics
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Scientist, Upstream Development
Company: Shape Therapeutics
Location: Seattle, WA
Posted Dec 08, 2023
Additional compensation may include annual target bonus and/or sign-on bonus, equity grant and relocation bonus. Efficiently organize time and resources to meet deadlines Maintain a detailed electronic laboratory notebook What you Bring: Preferred Qualifications: Bachelor of Science degree in Cellular Biology, Engineering, Biochemistry, Biology, or a related discipline with 5+ years of post-degree experience in an academic or industry research capacity or Masters with 2-3 years of post-degree experience Ph.D. in Cellular Biology, Engineering, Biochemistry, Biology, or a related discipline with 0-2 years post-degree experience. We are proud to offer a competitive paid parental leave benefit, an annual employee stipend for employees to use however they choose, a Flex Paid Time Off program (allowing flexible PTO for vacation, sick leave, and other purposes) and Company paid Long Term Disability. Employees are eligible to enroll in our Company’s voluntary 401k plan, voluntary Life/AD&D and Voluntary FSA’s. not only through our science, but also through our commitment to foster an inclusive environment that supports diverse perspectives and experiences. The hired applicant's placement within the range is based on qualifications and professional experience. The salary range for this role is $95,000-$145,000. Skills and Experience: Experience with aseptic technique and small-scale mammalian cell culture Experience with bioreactor operations Experience generating and analyzing large datasets to understand impact of process parameters on product yield and quality Experience with statistical software like JMP Prior experience in cell culture process optimization in an industry or academic setting is highly desirable Experience working with viral vectors is desirable Experience with electronic lab notebooks Ability to troubleshoot and think analytically Strong work ethic and a team player Ability to effectively communicate via email, interpersonally, and in presentation ShapeTX offers a robust benefits package, including but not limited to: Medical, Dental and Vision coverage for employees and their eligible dependents. What You’ll Do: Cell culture media optimization to improve viral vector yield and product quality Cell line and upstream process improvement and intensification Optimize small scale and bioreactor runs for optimum vector production Work with external partners on technology development projects Document technical results and best practices in ELNs, SOPs, summary reports, etc. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Boston, Massachusetts.
Scientist I/II, Neuroscience
Company: Voyager Therapeutics
Location: Cambridge
Posted Dec 06, 2023
Ability to thrive in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. Hands-on experience with molecular and cellular techniques including ELISA, RT-qPCR, ddPCR, and biochemical assay development. Strong background in cell culture, in vivo experimental methods, and readouts. Conducts ex vivo tissue, CSF and serum analysis (ELISA, western blot, RT-qPCR, etc.) Preferred Experiences Strong preference for a candidate with experience in AAV gene therapy Prior related experience, ideally with a biotechnology or other life sciences company, is preferred but not required. Prior experience in drug discovery for neurodegenerative diseases would be preferred. Good communication skills and ability to multi-task. Excellent organizational skill and attention to detail. Ability to analyze and present data independently to the research teams. Lastly, the Scientist I/II will bring their ex vivo expertise to process the tissues from the in vivo studies, likely with assays such as ddPCR, RT-qPCR, binding assays, activity assays, and/or immunohistochemistry.
Associate Scientist/Senior Associate Scientist, Vector Purification
Company: Shape Therapeutics
Location: Seattle, WA
Posted Dec 05, 2023
Experience with protein analysis techniques (SDS PAGE, ELISA, Western blotting, etc.) Experience with ultracentrifugation and gradient purification Experience with molecular biology techniques and analysis (DNA/RNA purification, qPCR, ddPCR, etc.) Additional compensation may include annual target bonus and/or sign-on bonus, equity grant and relocation bonus. We are proud to offer a competitive paid parental leave benefit, an annual employee stipend for employees to use however they choose, a Flex Paid Time Off program (allowing flexible PTO for vacation, sick leave, and other purposes) and Company paid Long Term Disability. Employees are eligible to enroll in our Company’s voluntary 401k plan, voluntary Life/AD&D and Voluntary FSA’s. not only through our science, but also through our commitment to foster an inclusive environment that supports diverse perspectives and experiences. The salary range for the Associate Scientist role is $82,000-$110,000, and the salary range for the Senior Associate Scientist is $92,000-$124,000. Ability to troubleshoot, think analytically, and tackle challenges with a problem-solving, can-do attitude A collaborative, team player and good lab citizen Passion for benchwork Demonstrates initiative & strong work ethic Exquisite attention to detail and organization Ability to work both independently and collaboratively in a team-science environment ShapeTX offers a robust benefits package, including but not limited to: Medical, Dental and Vision coverage for employees and their eligible dependents. What You’ll Do: Execute and coordinate planned experiments within the sub team Independently plan and execute rigorous and well-controlled experiments Perform AKTA based affinity & ion exchange chromatography purifications Ability to optimize current purification methods using broad understanding of biochemistry and chromatography Analysis of purified material (qPCR, ddPCR, ELISA, SDS PAGE, genome integrity) Analyze and communicate results in small team and project team settings What You Bring: Qualifications BS in biochemistry or a related scientific discipline with 5+ years of relevant industry experience OR MS candidates with 3+ years of relevant industry experience Skills and Experience AAV production, purification, or analytics experience Experience with protein purification (Affinity, AEX, SEC, etc.) The AAV production team generates recombinant AAV to support the research pipeline and ShapeTX’s novel RNAfixTM, RNAswapTM, and RNAskipTM technology platforms.
Senior Scientist, Medicinal Chemistry
Company: MOMA Therapeutics
Location: Cambridge
Posted Dec 08, 2023
MOMA Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. You work hard, you are kind to others, and you enjoy being a part of a collaborative team that gets stuff done. You enjoy being in an environment where data drives the direction of the science. You have deep experience interpreting and integrating biochemical, cellular and ADME data and implementing medicinal chemistry strategies to advance program chemical matter through all phases of drug discovery. You have a demonstrated skill set when it comes to scientific creativity and risk taking in solving complex medicinal chemistry problems. You have experience in and love complex problem solving through in-depth analysis of data or situations. You are a self-starter with demonstrated impact in medicinal chemistry and drug discovery as evidenced by performance and accomplishment. Job Summary: We are looking for In this role you will… Devise and implement medicinal chemistry strategies to achieve project / research goals Influence the selection of critical path activities to drive project progression Build strong partnerships with outsourced synthetic chemistry at partner CROs Effectively communicate medicinal chemistry strategies, innovative ideas and results, both informally and in meetings with colleagues and research management Work collaboratively across diverse functions to achieve corporate goals About you… You have a PhD degree in organic/medicinal chemistry, and at least 5 years of drug discovery experience in a pharmaceutical/biotechnology company, or a Masters degree in organic/medicinal chemistry and at least 10 years of experience. Will be part of an experienced and resilient team that is collectively unstoppable, trusts one another, and selflessly collaborates Will work with incredible humans who are committed to the discovery of transformative medicines for patients Are needed… because patients are counting on you About MOMA Therapeutics At MOMA Therapeutics, we are motivated by a single common goal, to discover and develop innovative new medicines for patients through our singular focus: the therapeutic targeting of molecular machines. Imagine joining a company where you….
Scientist / Senior Scientist, Proteomics
Company: Relay Therapeutics
Location: Cambridge
Posted Dec 05, 2023
Mass Spectrometric data analysis using Xcalibur, Chimerys/ Proteome Discoverer, MaxQuant, etc. You are self-motivated, enjoy working in a fast-paced dynamic team environment. Extensive hands-on experience in discovery proteomics including sample preparation, analytical method development, instrument operation, and data analysis. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. You have a track record of scientific excellence as reflected by high impact, peer reviewed publications and/or patents. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Knowledge of high-throughput quantitative proteomics methodologies such as TMT, SILAC and/or Label-free approaches is a must. Your Background: You earned a PhD in Bioanalytical Chemistry, Biochemistry, or a related discipline. You have experience working with targeted protein degraders and/or stabilizers.
QC Analyst, Bio-Analytical
Company: Spark Therapeutics, Inc.
Location: Philadelphia, PA
Posted Dec 08, 2023
Hands on experience in executing the following assays, qPCR, PCR, mammalian cell culture techniques, tissue-cultured assays, ELISAs, SDS-PAGE and Western blots, preferred. Critical thinking skill, ability to manage time, and skills in prioritizing, organization and time management. Strong background experience in executing and troubleshooting HPLC, UPLC and CE-SDS Assays, required. Possess good interpersonal and strong written/verbal communication skills. Spark takes into consideration a combination of candidate's education, training, and experience as well as the position's scope and complexity, the discretion and latitude required in the role, and external market and internal value when determining a salary for potential new employees. Highly motivated and detail oriented with good organizational skills. Must have experience with Empower and 32Karat Software. May need to be available for some weekend scheduled work. Experience working in a GMP environment is necessary. With supervision, complete deviation reports and investigations.
Associate / Senior Associate, Competitive Intelligence and Strategy
Company: Entrada Therapeutics
Location: Boston, MA
Posted Dec 06, 2023
Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. strongly preferred. Desire to work in a fast-paced, innovative, and collaborative environment. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. The Perks By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. Ability to create and present ideas effectively using Microsoft PowerPoint, Word, and Excel. 1-2 years of relevant experience, preferably in an analytical role such as market research, equity research, or life sciences consulting. Entrada Therapeutics is an equal opportunity employer. To thrive on our team, you will need to come with: Bachelor of Science or Arts degree in life sciences (biology, biochemistry, chemistry, etc.) Located in the Greater Boston Area.
Associate Director, Analytical Development
Company: Corcept Therapeutics
Location: Peninsula
Posted Dec 05, 2023
Responsibilities: Manage the development, qualification, validation, and transfer of analytical methods at contract laboratories. An annual cash bonus and equity grants may be provided as part of the overall compensation package, in addition to a full range of medical, financial, and/or other wellness benefits, dependent on the position offered. in chemistry or relevant field with 10+ years of development experience in pharmaceutical industry Excellent scientific knowledge of analytical chemistry and deep knowledge and experience of supporting pharmaceutical development and manufacturing of drug substance and various drug product dosage forms Must have hands-on experience with analytical development techniques used in the pharmaceutical industry including LC, LC-MS, GC, and Dissolution The pay range that the Company reasonably expects to pay for this position is $183,300 - $206,500; the pay ultimately offered may vary based on legitimate considerations, including job-related knowledge, skills, experience, and education. The position will also be responsible for authoring technical reports, deviations, change controls, and analytical sections of regulatory filings. If you are based in California, we encourage you to read this important information for California residents linked here. Review analytical data from contract partners, provide feedback, and facilitate resolution of technical or quality issues Manage release testing and stability testing of drug substance and drug product at contract laboratories Oversee CMO analytical deviation & quality event investigations, and resolution of out-of-specification (OOS) and out-of-trend (OOT) testing results Assist in the selection and management of contract laboratories Collaborate with other members of the CMC team to ensure timely release of clinical products and resolution of product investigations Author and review development reports, deviations, and change control documents Author and review analytical sections of regulatory submissions Preferred Skills, Qualifications, or Technical Proficiencies: Experience in analytical and regulatory requirements, including strong working knowledge of cGMPs, ICH, USP, and other relevant regulatory requirements Good technical understanding of all aspects of analytical testing for small molecule pharmaceutical products. The Associate Director, Analytical Development will manage outsourced analytical methods development and testing of drug substance and drug product. Experienced in drafting regulatory submissions Able to manage multiple projects effectively. Enjoy working independently and collaboratively as part of a CMC team Preferred Education and Experience: Ph.D. in chemistry or relevant field with 5+ years of development experience in the pharmaceutical industry or M.S. Experience in providing oversight for product release and stability testing at contract manufacturers and laboratories Experience in facilitating resolution of product investigations promptly Effective written and verbal communication skills.
Engineering Manager
Company: Click Therapeutics
Location: New York City, NY
Posted Dec 06, 2023
Click Therapeutics will conduct interviews face-to-face over Zoom. Manages performance, career growth, recruiting, onboarding and training. All job postings will be listed on the Click Therapeutics official career page. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Click Therapeutics in the U.S. and, if so, whether that authorization permits them to work in the job they seek. Competitive Salary with Annual Review | Cash Bonus | Stock Options | 5% 401(k) matching | Medical | Dental | Vision | Life Insurance | Voluntary Benefits | Unlimited PTO | Uber One | Nectar Rewards | One Medical | Fertility Support | Fitness Reimbursement | Bike Membership | Professional Development Stipend | Lunch Stipends | Parent Benefits | Industrious Workspaces | Commuter Subsidies | Flexible Work Arrangement | Choice of Mac or Windows | Sponsored Company Events | Office Snacks and Beverages | Much More...Equal Employment Opportunity:Click Therapeutics is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. If someone contacts you about a job or position that is not listed on the official career page, please contact the Click Therapeutics recruitment team at the contact information below. If you have any questions regarding the validity of a recruitment inquiry or an interview, please contact the Click's recruitment team at [email protected] to confirm before proceeding. The final base salary will be dependent upon skills, experience and location. All applicants must have authorization to work for Click Therapeutics in the U.S. Click Therapeutics may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons.
(Sr.) Bioinformatics Associate Scientist
Company: Shape Therapeutics
Location: Seattle, WA
Posted Dec 05, 2023
Additional compensation may include annual target bonus and/or sign-on bonus, equity grant and relocation bonus. We are proud to offer a competitive paid parental leave benefit, an annual employee stipend for employees to use however they choose, a Flex Paid Time Off program (allowing flexible PTO for vacation, sick leave, and other purposes) and Company paid Long Term Disability. Proven experience developing processing pipelines for raw next-generation sequencing (NGS) data Skills and Experience: Strong track record of developing and applying innovative and rigorous computational methodologies to high-throughput biological data Proficiency in Python and experience with Linux/Unix and open-source bioinformatics tools and databases Experience with collaborative development using version control systems (e.g., Git) and software development best practices (e.g., CI/CD, testing, code review) Experience using workflow management systems (e.g., Nextflow, Snakemake, CWL) preferred Exposure to cloud computing environments, high-performance computing, and containerization technologies (e.g., AWS Batch, SGE/SLURM, Docker) Experience in molecular biology and experimental design of -omic assays is a plus Ability to effectively manage one’s time and prioritize tasks to enable multiple projects Exquisite attention to detail, organization, and proactive communication Curious mindset and willingness to learn from and mentor others Ability to work both independently and collaboratively in a team-science environment Ability to take initiative to think outside the box and tackle challenges with a problem-solving, can-do attitude ShapeTX offers a robust benefits package, including but not limited to: Medical, Dental and Vision coverage for employees and their eligible dependents. not only through our science, but also through our commitment to foster an inclusive environment that supports diverse perspectives and experiences. What You’ll Do: Design and implement reproducible methods for processing NGS data, laying the groundwork for statistical and machine learning (ML) analyses that rigorously test biological hypotheses Interface with experimentalists to ensure fidelity across experimental and computational methods development Develop and maintain codebases using software design best practices: including testing, documentation, reproducibility, usability, and peer review Collaborate with diverse project teams to ensure the adoption of appropriate tools and analyses to inform decisions What You Bring: Qualifications and Requirements: Bachelor’s degree with relevant work experience or Master’s degree in Computational Biology, Statistics, Genomics, Bioinformatics, or a related discipline. Employees are eligible to enroll in our Company’s voluntary 401k plan, voluntary Life/AD&D and Voluntary FSA’s. The hired applicant's placement within the range is based on qualifications and professional experience. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Boston, Massachusetts. The salary range for a Bioinformatics Associate Scientist is $105,000-$140,000 and the salary range for a Sr. Bioinformatics Associate Scientist is $110,000-$155,000. Position Overview ShapeTX is looking for an enthusiastic, collaborative, and motivated Bioinformatics Associate Scientist to join our fast-growing Analytics and Informatics (AI) department.
Senior Scientist/Principal Scientist, Computational Biology
Company: MOMA Therapeutics
Location: Cambridge
Posted Dec 08, 2023
MOMA Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. TCGA, Depmap, String etc) You have a solid understanding of statistical/algorithmic principles and are fluent in R, Bioconductor and in one or more additional programming languages (Perl, Python or Java) You are comfortable working in multiple computing environments including cloud-based platforms You enjoy being in an environment where scientific data rules the day You work hard, you are kind to others, and you enjoy being a part of a collaborative team that gets stuff done You have an eagerness to participate in monthly potlucks (consuming and cooking) and provide creative potluck theme ideas. Regularly present strategy and scientific findings to the scientific and management leadership teams About you… You have completed a Post-doc and have 3-5 years oncology computational biology experience in academia or the pharmaceutical/biotech industry preferably You have a PhD in computational biology, bioinformatics, oncology, cellular and molecular biology, or genetics You have proven experience in effectively formulating and answering biological questions through computational analyses You're known as an expert when it comes to current and emerging public genomic/ proteomic databases (e.g. Integrate internal and external large-scale datasets to generate unique disease insights, explore drug mechanism of action, and directly impact drug discovery projects Collaborate with scientists and teams across the organization to drive the generation of actionable predictions that can be tested in the lab or the clinic. The computational sciences group is a cross-disciplinary team comprised of computational chemists, computational biologists, data scientists, cheminformaticians, and machine learners deeply embedded in our project teams and making contributions critical to MOMA’s mission. This includes bridging and communicating cross-functionally. This critical and dynamic role requires an exceptional ability to interrogate and refine biological hypotheses using large-scale cancer genomic data Implement and advance computational pipelines to analyze functional genomic screens to discover the next generation of targets MOMA will prosecute Provide project team support via exploration into target and resistance MOAs, as well as biomarker refinement. In this role you will… Enhance and drive the computational biology capability and strategy across the discovery organization. In this role, you will have the opportunity to shape the team and learn new areas of computational sciences by wearing many hats and see drug discovery from all angles. It is essential to be agile in this role to provide insight on early target ID to later-stage translational biology.
Scientist, Analytical Development
Company: LEXEO Therapeutics
Location: New York City, NY
Posted Dec 08, 2023
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment. regulations, compliance and current industry best practices Required Skills & Qualifications BS with 4+ years, MS with 2+ years or Ph.D. in chemistry, biochemistry, life sciences, pharmaceutical sciences, chemical engineering or equivalent Experience in cell and gene therapy products. Results oriented with breadth and depth in pharmaceutical development and commercial products to resolve complex problems Results oriented, has a bias for action. Location Lexeo Office located in New York, NY. Strong initiative, accountability and willingness to take ownership and drive projects to completion Accustomed to “roll up their sleeves” and execute the tasks needed in a small company environment Depending on qualifications and overall experience, base salary is likely to be $110,000-$125,000 per year. Primary Responsibilities Development of phase-appropriate testing methodologies – including such assays as digital PCR, potency, quantitative PCR – for AAV gene therapy vectors Assist in the development and internal testing of potency assays in a target-specific manner. Experience with pharmaceutical drug-process validation and manufacture a plus Knowledge of FDA, cGMPs, and ICH guidelines and QBD principles a plus Cross functional acumen and highly skilled in working with complex issues and creating direction in shifting priorities and ambiguity. This position requires collaborative skills, multi-tasking ability, and desire to strive in a fast-paced environment. Building in-house capability in analytical development for viral vectors Assist in driving the analytical strategy of the organization and support regulatory activities for filing Assist in collaborating with CDMOs and CROs to support production and release of GMP materials Participate in technical transfer between laboratories, qualification/validation of assays and QC activities for material release Timely development of assays as well as testing of samples for material release Identification and communication of risks in assay performance and their mitigation Provide support to the organization regarding analytical aspects, e.g. We are an early-stage company, so this is a highly visible and impactful role in our organization.