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Staff Data Engineer - (Durham NC or Menlo Park, CA) - #4571

Remote Posted Jul 01, 2026 0 views

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GRAILJobs
Staff Data Engineer - (Durham NC or Menlo Park CA) - #4571

Staff Data Engineer - (Durham NC or Menlo Park CA) - #4571

Reposted 6 Hours Ago
2 Locations
Hybrid
165K-206K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Software • Biotech
GRAIL is a healthcare company whose mission is to detect cancer early when it can be cured.
The Role
Lead the design and development of data systems for cancer detection collaborating with scientists and engineers to deliver robust datasets and improve data quality.
Summary Generated by Built In
Our mission is to detect cancer early when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative safe and effective technologies that can transform cancer care.

We are a healthcare company pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists engineers and physicians and we are using the power of next-generation sequencing (NGS) population-scale clinical studies and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California with locations in Washington D.C. North Carolina and the United Kingdom. It is supported by leading global investors and pharmaceutical technology and healthcare companies.

For more information please visit grail.com

GRAIL’s Research department is seeking a Staff Data Engineer to lead the design development and evolution of data systems that power GRAIL’s product pipeline from sample collection through processing analysis and regulatory submission. This role operates at the intersection of computational science engineering and clinical research enabling high-impact decision-making across the organization.

The Staff Data Engineer is a technical leader who partners with scientists statisticians and engineering teams to shape system architecture and deliver robust analysis-ready datasets. This individual operates with a high degree of autonomy tackling complex and ambiguous challenges and influencing cross-functional teams to align on data standards best practices and long-term solutions.

They will develop deep expertise in GRAIL’s end-to-end data lifecycle including EDC LIMS Bioinformatics Pipelines and TidyData an internally-developed system that aggregates and serves combined datasets. They will lead efforts to improve interoperability scalability and data quality across these systems.

The Staff Data Engineer will also collaborate with software engineers and scientists to develop dataset requirements develop code and procedures to support dataset generation perform QC and troubleshoot issues that arise. As needed the Staff Data Engineer will also contribute to new reporting data visualization and statistical analysis features.

Impact & Scope
  • Own and drive large complex data initiatives that impact multiple teams and stages of the product pipeline

  • Define and evolve data architecture standards and best practices across systems

  • Influence technical direction and strategy for data engineering within Research and partner organizations

  • Act as a subject matter expert and technical leader guiding others and elevating team capabilities

  • Solve ambiguous high-impact problems requiring deep technical judgment and cross-domain understanding

This is a hybrid role based in either Menlo Park CA (moving to Sunnyvale CA in Fall 2026) or Durham NC. Our current flexible work arrangement policy requires that a minimum of 60% or 24 hours of your total work week be on-site. Your specific schedule determined in collaboration with your manager will align with team and business needs and could exceed the 60% requirement for the site.

Responsibilities

  • Collaborate with data scientists biostatisticians and clinical teams to deliver data solutions and sample selections that support clinical trial and research analysis goals

  • Translate complex scientific and analytical requirements into robust reusable data solutions

  • Contribute to data quality frameworks including standards for validation reconciliation and observability across datasets

  • Drive self-service data platform strategy implementation and tooling adoption through training and documentation

  • Lead efforts to standardize and improve dataset generation QC and reporting workflows

  • Evaluate and introduce new technologies methodologies and best practices to improve data management in a regulated biotechnology environment

  • Mentor other engineers and contribute to technical leadership standards and best practices across the organization

  • These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion

  • These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion

Required Qualifications

  • BS with 8+ years MS with 5+ years or PhD with 3+ years of experience in a computational or scientific field (life science computer science engineering mathematics statistics bioinformatics etc.)

  • Advanced proficiency in Python or R with strong software engineering fundamentals

  • Demonstrated experience designing end-to-end data systems and architectures — from ingestion and transformation to orchestration and visualization

  • Deep understanding of data modeling pipelines orchestration and data quality practices

  • Proven ability to lead complex cross-functional projects with significant business or scientific impact

  • Strong communication skills with the ability to influence technical and non-technical stakeholders

  • Experience operating with high autonomy in ambiguous problem spaces

  •  

Preferred Qualifications

  • Experience with distributed systems or system-level programming (Go Java C++)

  • Familiarity with bioinformatics clinical data systems or molecular biology concepts

  • Experience with cloud platforms (AWS) and modern data infrastructure

  • Experience driving technical strategy standards or platform adoption

  • Intermediate experience with AI-assisted development workflows

  • Strong SQL and data warehousing expertise

Expected full time annual base pay scale for this position is $190-237k in Menlo Park CA and $165k-206K in Durham NC. Actual base pay will consider skills experience and location.

This role may be eligible for other forms of compensation including an annual bonus and/or incentives subject to the terms of the applicable plans and Company discretion. This range reflects a good-faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package offered in accordance with our applicable plans and policies. This package currently includes flexible time-off or vacation; a 401(k) retirement plan with employer match; medical dental and vision coverage; and carefully selected mindfulness programs.

GRAIL is an equal employment opportunity employer and we are committed to building a workplace where every individual can thrive contribute and grow. All qualified applicants will receive consideration for employment without regard to race color religion national origin sex gender gender identity sexual orientation age disability status as a protected veteran or any other class or characteristic protected by applicable federal state and local laws. Additionally GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at [email protected] if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!

Skills Required

  • BS with 8+ years MS with 5+ years or PhD with 3+ years of experience in a computational or scientific field
  • Advanced proficiency in Python or R
  • Experience designing end-to-end data systems and architectures
  • Deep understanding of data modeling pipelines orchestration and data quality practices
  • Proven ability to lead complex cross-functional projects
  • Strong communication skills to influence stakeholders
  • Experience operating with high autonomy in ambiguous problem spaces
  • Experience with distributed systems or system-level programming (Go Java C++)
  • Familiarity with bioinformatics clinical data systems or molecular biology concepts
  • Experience with cloud platforms (AWS) and modern data infrastructure
  • Intermediate experience with AI-assisted development workflows
  • Strong SQL and data warehousing expertise

What the Team is Saying

Neda Ronaghi
Ruth Mauntz
Tristan Matthews
David Jenions
Satnam Alag

GRAIL Compensation & Benefits Highlights

  • Healthcare StrengthComprehensive medical dental vision and mental‑health resources are offered with FSAs/HSAs and multiple carrier options. Feedback suggests the company covers a large share of premiums enhancing perceived value.
  • Leave & Time Off BreadthFlexible/“unlimited” time off sick time paid holidays and summer/winter shutdowns provide broad time‑off options. Hybrid/remote work further expands flexibility for many roles.
  • Equity Value & AccessibilityAn ESPP with a discounted purchase feature and equity grants provide accessible ownership upside confirmed by company filings. Feedback suggests equity is a meaningful part of total rewards.

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The Company
HQ: Menlo Park CA
918 Employees
Year Founded: 2016

What We Do

GRAIL is a healthcare company whose mission is to detect cancer early when it can be cured. GRAIL is using the power of high-intensity sequencing population-scale clinical studies and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology and to develop and commercialize pioneering products.

Why Work With Us

Everything we do is guided by our mission to detect cancer early when it can be cured. It’s the reason we’re here and it’s no small task. The right people make all the difference. That’s why we’re looking for those who strive to share their knowledge contribute their skills inspire each other and commit to something bigger than themselves.

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GRAIL Offices

Hybrid Workspace

Employees engage in a combination of remote and on-site work.

GRAIL has a variety of work types depending on the roles. Some roles are onsite like a lab role some are fully remote like our Galleri Sales Consultant roles. Others are hybrid with 2-3 days onsite. Typically Tuesday and Thursday.

Typical time on-site: 2 days a week
Company Office Image
HQMenlo Park CA
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London GB
Company Office Image
Raleigh NC
Company Office Image
Washington DC
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