Tech Jobs in St. Louis, MO

61,353 open positions · Updated daily

St. Louis is becoming a tech hub thanks to a blend of healthcare innovation, a strong manufacturing base, and a growing fintech scene. With 14,708 tech openings, the city offers a mix of high‑growth startups and established firms, all powered by a talent pool fed by universities such as Saint Louis University and Washington University.

Key sectors driving the market include healthtech—home to life‑science giants like BJC HealthCare and Eli Lilly—financial technology, logistics software, and data analytics. Companies like Enterprise Holdings, Vontel, and the City of St. Louis use cutting‑edge platforms to streamline operations, while startups in the Central West End and Midtown districts are hiring full‑stack developers, AI/ML engineers, and cybersecurity specialists.

While the cost of living in St. Louis remains 15% below the national average, median rent for a one‑bedroom apartment in Midtown is around $1,200 and the median home price sits near $225,000. Transparent salary listings let candidates evaluate whether a role’s pay aligns with local living expenses—ensuring you can afford the lifestyle you want without hidden surprises.

Lead Program Security Engineer

Company: Mastercard

Location: O'Fallon, MO

Posted Jan 24, 2025

Mastercard is seeking a Lead Program Security Engineer in London to support the Enterprise Data Accessibility program. The role involves providing technical design and architecture advice for securely developing applications and systems, defining guidance for securing critical business functions in cloud environments, and working closely with development teams to meet security and regulatory requirements. The ideal candidate should have a strong understanding of information security, risk, and data privacy within digital commerce, experience in secure development disciplines, and knowledge of virtualization platforms like AWS, VMware, Google Cloud, OpenStack, or Azure. They should also have experience with continuous delivery/integration processes, secure coding best practices, and UNIX, Linux, Solaris, or AIX.

Student Worker

Company: Sodexo

Location: Warrensburg, MO

Posted Jan 24, 2025

Travel Nurse RN - Med Surg - $1,791 per week

Company: Host Healthcare

Location: St. Louis, Missouri

Posted Jan 24, 2025

Host Healthcare is currently recruiting a travel nurse RN for a 13-week Med Surg position in St. Louis, Missouri. The job offers competitive pay, benefits including medical, dental, vision, license reimbursement, and housing support. Host Healthcare is recognized as the top-ranked travel healthcare company in the U.S., providing a worry-free travel experience with dedicated recruiters and 24/7 support.

Pharmacy Intern

Company: CVS Health

Location: St. Louis, MO

Posted Jan 24, 2025

CVS Health is offering a 3rd year pharmacy intern position with opportunities for professional growth and making a significant impact in healthcare. The role involves ensuring patient safety, managing pharmacy operations, and delivering exceptional customer service. Interns will work under a licensed pharmacist, participating in patient care programs, and demonstrating empathy and compassion. The position requires strong communication skills, relevant work experience, and valid intern/technician licensure. Preferred qualifications include immunization eligibility and proficiency in Microsoft Office Suite.

Business Account Executive

Company: Spectrum

Location: Jefferson City, MO

Posted Jan 24, 2025

Loss Prevention Associate II

Company: The TJX Companies, Inc.

Location: Columbia, MO

Posted Jan 24, 2025

Marshalls Store 1097 in Columbia, MO is seeking a Loss Prevention Officer. The role involves acting as a visual deterrent to prevent potential loss, greeting customers, and reporting suspicious behavior. The company culture is dynamic, encouraging discovery and change, with a focus on providing a positive customer experience. Benefits include a discount, 401(k) contributions, and various insurances. The starting pay range is $13.75 to $18.25 per hour.

Backroom Coor

Company: The TJX Companies, Inc.

Location: Columbia, MO

Posted Jan 24, 2025

HomeGoods Store 1197 in Columbia, MO is seeking a flexible, organized, and team-oriented individual for a merchandising role. The position involves executing receiving and merchandising standards, ensuring a clean and organized store, and providing excellent customer service. The ideal candidate should have 1 year of retail experience and 6 months of leadership experience, with the ability to lift heavy objects, communicate effectively, and multi-task. HomeGoods values a culture of honesty, integrity, and diversity, offering opportunities for career growth and development.

(USA) Personal Shopper - Sam's

Company: Walmart

Location: Raymore, MO

Posted Jan 24, 2025

The job involves developing and supporting membership by providing information on benefits, promoting products, processing memberships, and meeting goals. It also includes maintaining facility safety, fulfilling member orders, providing member service, and complying with company policies. The role emphasizes respect for individuals, integrity, customer service, striving for excellence, and teamwork. Benefits include competitive pay, health benefits, financial benefits, paid time off, and other perks like disability coverage, company discounts, and education benefits.

Operations Manager

Company: Rentokil Terminix

Location: Columbia, MO

Posted Jan 24, 2025

The job posting is for a position responsible for in-field training, coaching, supervision, and monitoring of service professionals. The role involves directing, motivating, and providing continuous training to ensure quality service. The job requires 1-2 years of industry experience and a high school diploma or equivalent. The company, Rentokil, offers benefits starting on the first day for full-time colleagues, with no waiting period. Rentokil is a global leader in pest control and other services, committed to protecting people, enhancing lives, and preserving the planet.

Frequently Asked Questions

What types of tech jobs are available in St. Louis, MO?
St. Louis offers roles from software engineering and data science to cybersecurity, DevOps, UI/UX design, AI/ML research, and product management. The city’s healthtech and fintech sectors demand specialists in electronic health records, blockchain, and regulatory tech, while logistics firms need supply‑chain analytics and IoT developers.
How do remote and on‑site trends look in St. Louis?
Many companies now support hybrid models, with on‑site work preferred for roles that require collaboration, such as product design or systems engineering. Pure remote positions are common in software development and data analysis. Companies like Enterprise and Vontel offer flexible schedules, but a 3‑day on‑site requirement is typical for senior engineering roles.
Who are the major employers in St. Louis?
Key employers include BJC HealthCare, Enterprise Holdings, Eli Lilly & Co., Vontel, City of St. Louis, and the St. Louis Science Center’s research labs. Additionally, the city’s startup ecosystem includes companies such as Glean, Tasty, and the Midtown tech incubator, all actively hiring tech talent.
What are salary expectations for tech roles in St. Louis?
Median base salary for software engineers in St. Louis is around $95,000, with senior roles reaching $120,000+. Data scientists average $98,000, while cybersecurity analysts earn $88,000. These figures exceed the national average for comparable roles, reflecting the city’s focus on high‑growth industries. Transparent listings on Job Transparency help you benchmark offers against local market rates.
What advice is there for relocating to St. Louis for tech work?
Plan your move by researching neighborhoods: Midtown and the Central West End offer vibrant tech scenes and affordable housing; the St. Louis Riverfront and Oakville provide quieter options with easy access to downtown. Use Job Transparency’s salary tool to confirm that offers cover living costs. When interviewing, ask about relocation packages, housing stipends, and the company’s remote policy. Finally, tap local networking groups such as the St. Louis Tech Council and meetups to accelerate integration.

Related Pages