Tech Jobs in St. Louis, MO

61,353 open positions · Updated daily

St. Louis is becoming a tech hub thanks to a blend of healthcare innovation, a strong manufacturing base, and a growing fintech scene. With 14,708 tech openings, the city offers a mix of high‑growth startups and established firms, all powered by a talent pool fed by universities such as Saint Louis University and Washington University.

Key sectors driving the market include healthtech—home to life‑science giants like BJC HealthCare and Eli Lilly—financial technology, logistics software, and data analytics. Companies like Enterprise Holdings, Vontel, and the City of St. Louis use cutting‑edge platforms to streamline operations, while startups in the Central West End and Midtown districts are hiring full‑stack developers, AI/ML engineers, and cybersecurity specialists.

While the cost of living in St. Louis remains 15% below the national average, median rent for a one‑bedroom apartment in Midtown is around $1,200 and the median home price sits near $225,000. Transparent salary listings let candidates evaluate whether a role’s pay aligns with local living expenses—ensuring you can afford the lifestyle you want without hidden surprises.

Staff Pharmacist

Company: Walmart

Location: Springfield, MO

Posted Jan 24, 2025

Pharmacy Technician

Company: CVS Health

Location: Fenton, MO

Posted Jan 24, 2025

CVS Health is inviting applications for Pharmacy Technicians, emphasizing their commitment to human-centric healthcare. The role involves delivering compassionate care, managing pharmacy workstations, and ensuring regulatory compliance. New hires must complete a training program and meet state board of pharmacy requirements. The position offers opportunities for career growth and a range of benefits, including medical, dental, vision, 401(k), life insurance, disability benefits, and well-being programs.

Nurse Practitioner - HouseCalls - Boone and Callaway County, MO

Company: UnitedHealth Group

Location: Columbia, MO

Posted Jan 24, 2025

Optum is offering a $10,000 sign-on bonus for an external candidate to join their HouseCalls team as a Nurse Practitioner in Colombia, MO. The role involves conducting in-home assessments, performing evidence-based practice screenings, and educating members on health topics. Optum is a clinician-led care organization that aims to provide seamless health journeys for patients across the care continuum. The successful candidate will be rewarded for their performance and have opportunities for development. Required qualifications include an active NP license, ANCC or AANP certification, and the ability to complete physical requirements of the job.

Pharmacy Intern - Grad

Company: CVS Health

Location: Branson, MO

Posted Jan 24, 2025

CVS Health offers challenging opportunities for pharmacist interns to learn and grow professionally, contributing to better healthcare. As a Graduate Pharmacist Intern, you'll work under a licensed pharmacist, ensuring patient safety, and delivering exceptional care. Key responsibilities include leading with heart, supporting pharmacy staff, identifying business opportunities, and driving growth. Required qualifications include a PharmD degree, relevant work experience, and valid pharmacist intern/technician licensure. Preferred qualifications include immunization eligibility and proficiency in Microsoft Office Suite.

Pharmacy Intern Grad

Company: CVS Health

Location: Maryland Heights, MO

Posted Jan 24, 2025

CVS Health offers challenging opportunities for pharmacist interns to learn and grow professionally, contributing to better healthcare. As a Graduate Pharmacist Intern, you'll work under a licensed pharmacist, ensuring patient safety, and delivering exceptional care. Key responsibilities include leading with heart, supporting pharmacy staff, identifying business opportunities, and driving growth. Required qualifications include a PharmD degree, relevant work experience, and valid pharmacist intern/technician licensure. Preferred qualifications include immunization eligibility and proficiency in Microsoft Office Suite.

Order Processing Specialist

Company: Hitachi Energy

Location: Maryland Heights, MO

Posted Jan 24, 2025

Grocery Clerk

Company: Kroger

Location: Rolla, MO

Posted Jan 24, 2025

Store Associate

Company: CVS Health

Location: Florissant, MO

Posted Jan 24, 2025

CVS Health is seeking Retail Store Associates to join their team, emphasizing a human-centric approach to healthcare. The role involves providing excellent customer service, maintaining the sales floor, supporting store activities, and assisting in the pharmacy. The company offers competitive pay, comprehensive benefits, and opportunities for career growth. No prior retail experience is required, but a high school diploma is preferred.

Food Service Manager

Company: Aramark

Location: St. Louis, MO

Posted Jan 24, 2025

Software Engineer II

Company: Mastercard

Location: O'Fallon, MO

Posted Jan 24, 2025

Mastercard is seeking a skilled Software Engineer with extensive experience in automating workflows, managing microservices, and implementing robust security measures within cloud environments. The ideal candidate should have a strong background in GitHub, GitHub Actions, and cloud-native architectures. The role involves full stack development, DevOps automation, authentication and authorization, microservices architecture, continuous improvement, and cloud experience. Preferred skills include experience with API documentation tools, GitHub Actions, and familiarity with cloud-native services. Mastercard offers competitive compensation and benefits, including health insurance, flexible spending accounts, paid leaves, 401k with a company match, and more.

Custodial Services Worker

Company: Aramark

Location: Kansas City, MO

Posted Jan 24, 2025

Pharmacy Intern - Grad

Company: CVS Health

Location: Kansas City, MO

Posted Jan 24, 2025

CVS Health offers challenging opportunities for pharmacist interns to learn and grow professionally, contributing to better healthcare. As a Graduate Pharmacist Intern, you'll work under a licensed pharmacist, ensuring patient safety, and delivering exceptional care. Key responsibilities include leading with heart, supporting pharmacy staff, identifying business opportunities, and driving growth. Required qualifications include a PharmD degree, relevant work experience, and valid pharmacist intern/technician licensure. Preferred qualifications include immunization eligibility and proficiency in Microsoft Office Suite.

Frequently Asked Questions

What types of tech jobs are available in St. Louis, MO?
St. Louis offers roles from software engineering and data science to cybersecurity, DevOps, UI/UX design, AI/ML research, and product management. The city’s healthtech and fintech sectors demand specialists in electronic health records, blockchain, and regulatory tech, while logistics firms need supply‑chain analytics and IoT developers.
How do remote and on‑site trends look in St. Louis?
Many companies now support hybrid models, with on‑site work preferred for roles that require collaboration, such as product design or systems engineering. Pure remote positions are common in software development and data analysis. Companies like Enterprise and Vontel offer flexible schedules, but a 3‑day on‑site requirement is typical for senior engineering roles.
Who are the major employers in St. Louis?
Key employers include BJC HealthCare, Enterprise Holdings, Eli Lilly & Co., Vontel, City of St. Louis, and the St. Louis Science Center’s research labs. Additionally, the city’s startup ecosystem includes companies such as Glean, Tasty, and the Midtown tech incubator, all actively hiring tech talent.
What are salary expectations for tech roles in St. Louis?
Median base salary for software engineers in St. Louis is around $95,000, with senior roles reaching $120,000+. Data scientists average $98,000, while cybersecurity analysts earn $88,000. These figures exceed the national average for comparable roles, reflecting the city’s focus on high‑growth industries. Transparent listings on Job Transparency help you benchmark offers against local market rates.
What advice is there for relocating to St. Louis for tech work?
Plan your move by researching neighborhoods: Midtown and the Central West End offer vibrant tech scenes and affordable housing; the St. Louis Riverfront and Oakville provide quieter options with easy access to downtown. Use Job Transparency’s salary tool to confirm that offers cover living costs. When interviewing, ask about relocation packages, housing stipends, and the company’s remote policy. Finally, tap local networking groups such as the St. Louis Tech Council and meetups to accelerate integration.

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