Jobs at Flagship Pioneering

Positions 43,513

Flagship Pioneering is a venture capital firm that builds companies from the ground up in biotech, health tech, and data‑driven science. Founded in 2014, the firm invests in early‑stage startups that translate scientific breakthroughs into market‑able products. With offices in Boston and San Francisco, Flagship partners with founders to provide capital, strategic guidance, and operational expertise.

Hiring at Flagship spans technical, scientific, and business disciplines. Current openings include Software Engineer – AI, Data Scientist – Genomics, Product Manager – Digital Health, Bioinformatics Analyst, Regulatory Affairs Specialist, and Sales & Marketing roles for emerging therapeutics. Candidates can expect rigorous interview processes that test domain knowledge, problem‑solving, and cultural fit within a fast‑moving, collaborative environment.

Job Transparency’s Flagship listings give applicants the edge by revealing exact salary ranges, bonus structures, and employee sentiment scores. Access to real‑time market data lets you benchmark offers against industry averages and negotiate confidently. The platform also aggregates interview feedback, helping you tailor your preparation and highlight the skills most valued by Flagship’s hiring teams.

Senior Scientist, Proteomics

Company: Flagship Pioneering

Location: Cambridge

Posted May 27, 2024

FL94 is a biotech company seeking a Proteomics Scientist to join their team. The ideal candidate will have expertise in chemical biology, experience with mass spectrometry workflows, and a strong understanding of proteomics sample prep. They should be able to independently analyze proteomics data, have experience with large-scale data interpretation, and possess excellent communication skills. The company is committed to equal employment opportunity and values diversity.

Senior Scientist, Immuno-oncology

Company: Flagship Pioneering

Location: Cambridge

Posted May 12, 2024

Quotient Therapeutics, a Flagship Pioneering company, is seeking a Scientist with an immuno-oncology background to validate novel oncology targets using in vitro and in vivo models. The ideal candidate will have a Ph.D. in Immunology, Oncology, Cell Biology, or a related field, with extensive hands-on experience in mammalian cell culture and primary cells. They should be proficient in experimental design, assay execution, data analysis, and interpretation. Experience in tumor animal model design, PK and PD analysis, and techniques such as FACS, ELISA, MSD, WB, RT-qPCR, cell culture, microscopy, IHC, and quantitative image analysis is a plus. The role involves designing, planning, and executing high-quality in vitro assays, leading animal studies, and mentoring research associates.

IP Counsel

Company: Flagship Pioneering

Location: Cambridge

Posted May 05, 2024

Flagship Pioneering is a biotech company that invents and builds platform companies to revolutionize human health and sustainability. They unite life science innovation, company creation, and capital investment under one roof. Their companies have addressed urgent challenges like COVID-19 vaccination and curing intractable diseases. They offer inspiring leadership, competitive compensation, and impactful work. They seek an Intellectual Property Counsel with strong technical and patent skills in computational arts, life science technologies, and proven patent portfolio development skills.

(Senior) Research Associate, Protein Sciences

Company: Flagship Pioneering

Location: Cambridge

Posted May 27, 2024

Flagship Labs 97 Inc. (FL97) is recruiting for a (Sr.) Research Associate, Protein Sciences. The role involves developing methods for protein synthesis, optimizing RNA and protein production, and collaborating with interdisciplinary teams to build AI-driven processes. The ideal candidate should have a degree in biochemistry, molecular biology, or a related field, with at least 2 years of experience in protein expression, purification, and assay. Familiarity with Python programming is a plus. FL97 is part of Flagship Pioneering, a biotech company that invents and builds platform companies to transform health care, agriculture, and sustainability.

Senior Scientist, In Vitro Pharmacology

Company: Flagship Pioneering

Location: Cambridge

Posted May 27, 2024

Metaphore, founded by Flagship Pioneering in 2021, is seeking a Senior Scientist with a multidisciplinary background to lead biology and in vitro pharmacology activities. The ideal candidate should have industry experience, a strong track record in developing novel assays, and expertise in biologics development, particularly in immunology, metabolism, and antibody development. The role involves leading platform development initiatives, developing research plans, and collaborating with Discovery and Computational Biology teams. Key responsibilities include designing and implementing in vitro and ex vivo assays, managing direct reports, and preparing comprehensive data packages.

(Senior) Machine Learning Engineer, GPU Scaling

Company: Flagship Pioneering

Location: Cambridge

Posted May 05, 2024

FL94 Inc., a biotechnology company backed by Flagship Pioneering, is seeking a Machine Learning Engineer to lead efforts in training massive generative models and building a robust infrastructure for data flow. The ideal candidate will have experience in MLOps, Python, deep learning libraries, cloud computing, and data pipelining tools. They will work closely with ML scientists, biologists, and chemists to automate a design-build-test cycle for ML generated small molecules. The role involves building scalable machine learning pipelines, designing data processing pipelines, and working in a collaborative CI/CD environment. Flagship Pioneering is committed to equal employment opportunity and building diverse and inclusive teams.

Senior Research Associate, Nucleic Acids Biochemistry (Contract)

Company: Flagship Pioneering

Location: Cambridge

Posted May 27, 2024

Ring Therapeutics Inc., a biotechnology company, is seeking a Senior Research Associate to join their Nucleic Acids Biochemistry team. The role involves developing new Nucleic Acid viral payload modalities using various techniques such as molecular cloning, liquid chromatography, cell culture, imaging, digital/qPCR, and flow cytometry. The ideal candidate should have a B.S./B.A. in Biology or related field with 3+ years of experience or an MS degree with 1+ years of experience. Key qualifications include hands-on experience in molecular biology techniques, excellent aseptic technique, and strong communication skills.

Scientist I, Downstream Process Development (Contract)

Company: Flagship Pioneering

Location: Cambridge

Posted May 12, 2024

Ring Therapeutics Inc., a biotechnology company, is seeking a Scientist I for its Downstream Process Development team. The role involves establishing and developing an in vitro viral vector platform, focusing on high-throughput screening of chromatographic media, cell lysis and depth filtration processes, and bionanoparticle formulations development. The candidate will lead experimental design, strategy, execution, and analysis of data sets, and work cross-functionally with R&D to assess platform fit of new product candidates. The ideal candidate should have a PhD or equivalent experience in bioengineering, chemical engineering, biology, virology, biochemistry, or related fields, with experience in the development of non-enveloped VLPs, viral vectors, or other ATMPs, and extensive knowledge of key unit operations.

Principal Scientist, Machine Learning (Large Language Models)

Company: Flagship Pioneering

Location: Cambridge

Posted May 12, 2024

Flagship Labs 97 Inc. (FL97) is seeking an experienced Principal Scientist, ML (LLMs) to join their team. The ideal candidate should have a machine learning background, with previous experience building large-scale generative models, complex pre-processing pipelines, and comprehensive benchmarks to support scientific tasks. FL97 is part of Flagship Pioneering, an innovation enterprise that has created over 100 groundbreaking companies since 2000. Working at FL97, the candidate would have access to advanced technology in AI experimental design, automated liquid handling, and generative molecular design.

Principal Software Engineer

Company: Flagship Pioneering

Location: Cambridge

Posted Jun 04, 2024

Flagship Labs 104 (FL104) is seeking a Principal Software Engineer to join their scientific team. The role involves designing, developing, and applying LLM-based software for scientific reasoning. The successful candidate will lead system architecture for a SaaS application, spearhead LLM systems, guide cloud infrastructure design, promote collaborative software development, and streamline application deployment. Qualifications include a degree in computer science, extensive industry experience, and proficiency in Python, AWS, and CI/CD pipelines. The position offers the opportunity to collaborate with a talented team, contribute to a pioneering company, and work in a proactive, cross-functional environment.

Lead AI Scientist

Company: Flagship Pioneering

Location: Cambridge

Posted May 18, 2024

Quotient Therapeutics, a privately held early-stage company, is seeking a Lead AI Scientist to leverage genomics data and AI for developing novel therapeutics. The company, founded by Flagship Pioneering, has a strong track record in creating life sciences companies. The role involves developing computational methods, leading a team, collaborating with wet lab and data infrastructure teams, and communicating findings. Requirements include a PhD in genomics or computational biology, 3-7 years of industry experience, and strong leadership skills.

Scientist, Virology

Company: Flagship Pioneering

Location: Cambridge

Posted May 05, 2024

Apriori Bio, an early-stage biotechnology company, is seeking a Scientist with expertise in molecular virology, lentiviral pseudotyping, and lentiviral vector production. The company, founded by Flagship Pioneering, aims to develop a revolutionary R&D platform for neutralizing a wide range of infectious pathogens. The ideal candidate will design and optimize cell culture processes for lentivirus production, scale up production using engineered cell systems, and collaborate with a matrixed team of scientists and computational biologists.

Frequently Asked Questions

What is it like to work at Flagship Pioneering?
<strong>Mission‑driven culture</strong> – employees tackle long‑term scientific challenges and enjoy ownership in the companies they help build. Teams cross‑function between biology, engineering, and business, fostering rapid iteration. Flagship offers flexible schedules, generous equity packages, and a focus on continuous learning through internal workshops and external conferences.
What types of positions are available at Flagship Pioneering?
Flagship hires across four main tracks: <em>Biotech & Life Sciences</em> (e.g., Bioinformatics Analyst, Regulatory Affairs Specialist), <em>Data & AI</em> (Software Engineer, Data Scientist), <em>Product & Operations</em> (Product Manager, Program Manager), and <em>Commercial & Strategy</em> (Sales, Marketing, Corporate Development). Each role emphasizes domain expertise, analytical rigor, and the ability to thrive in a startup environment.
How can I stand out as an applicant for Flagship Pioneering?
Align your portfolio with Flagship’s mission by highlighting projects that translate science into marketable solutions. Showcase quantitative impact (e.g., algorithm performance metrics, assay validation data). Build a concise résumé that maps your experience to the job description, and prepare for case interviews by practicing problem‑solving under time constraints. Leverage alumni networks, attend virtual company events, and submit a tailored cover letter that cites specific Flagship initiatives.

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