Senior Director, Strategic Portfolio Management
Job Description
Team: Project Management
This position is posted by Jobgether on behalf of a partner company. We are currently looking for a Senior Director, Strategic Portfolio Management in the United States.
This is a high-impact leadership opportunity for an experienced portfolio management professional to shape and optimize a global R&D pipeline within a dynamic healthcare environment. The role focuses on driving strategic portfolio decisions that balance scientific innovation, financial performance, and long-term business value. Working closely with senior executives and cross-functional teams, the successful candidate will oversee portfolio governance, investment prioritization, scenario planning, and resource allocation across a broad range of development programs. This position offers the opportunity to influence enterprise-level strategy while leading a culture of data-driven decision-making and operational excellence. The role is ideal for professionals who thrive in complex, matrixed organizations and are passionate about advancing healthcare innovation on a global scale. Candidates will play a critical role in aligning scientific ambition with sustainable growth and organizational priorities.
Accountabilities:
- Lead enterprise-wide R&D portfolio reviews and annual strategic workplan processes to ensure alignment with corporate goals and therapeutic priorities.
- Drive portfolio optimization across therapeutic areas, modalities, development stages, and risk profiles to maximize long-term value creation.
- Provide strategic recommendations through data-driven prioritization, scenario analysis, and investment trade-off evaluations.
- Support governance forums and executive decision-making processes related to portfolio investments, milestone progression, acceleration, or discontinuation of programs.
- Integrate scientific, clinical, operational, financial, and commercial insights into portfolio strategy and planning activities.
- Oversee financial forecasting, capital allocation, headcount planning, and external spending considerations tied to R&D initiatives.
- Develop and maintain portfolio analytics, dashboards, metrics, and executive-level reporting tools to improve visibility and decision quality.
- Collaborate cross-functionally with development, regulatory, commercial, finance, manufacturing, and business development teams.
- Support evaluation of external opportunities including licensing, partnerships, collaborations, and acquisition initiatives.
- Build and mentor a high-performing strategic portfolio management team while promoting transparency, accountability, and evidence-based decision-making.
- Bachelor’s degree required; advanced degree such as PhD, MD, PharmD, MSc, or MBA strongly preferred.
- Minimum 15 years of experience within pharmaceutical or biotech R&D environments, including leadership roles in portfolio or program management.
- Strong expertise in strategic portfolio management, investment governance, and R&D strategy development.
- Deep understanding of drug development processes, clinical development, and R&D financial modeling.
- Experience supporting executive leadership teams and contributing to enterprise-level strategic decisions.
- Strong analytical and financial acumen with the ability to synthesize complex scientific and business data into actionable recommendations.
- Proven ability to work effectively within highly matrixed and globally distributed organizations.
- Excellent communication, presentation, negotiation, and stakeholder management skills, including executive and board-level interactions.
- Strong leadership capabilities with experience building collaborative, high-performing teams.
- PMP, PgMP, or equivalent program management certification is considered an advantage.
- Ability to manage complexity, uncertainty, and long development timelines while maintaining strategic focus and operational execution.
- Competitive salary range of $151,000 – $314,000 USD annually.
- Comprehensive healthcare and wellness benefits package.
- Retirement savings and financial planning benefits.
- Remote work flexibility within the United States.
- Inclusive and collaborative global work environment.
- Opportunities for leadership growth and career advancement.
- Exposure to enterprise-level strategic initiatives and executive leadership.
- Supportive culture focused on innovation, collaboration, and professional development.
- Opportunity to contribute to healthcare solutions impacting patients worldwide.
- Diverse and globally connected workplace with strong commitment to inclusion and equal opportunity.
Requirements:
Benefits:
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Date Posted
05/20/2026
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