Tech Jobs in SAINT LOUIS, Missouri

49,974 open positions · Updated daily

Saint Louis has become a magnet for tech talent as the city blends a strong manufacturing legacy with a growing fintech and healthcare IT scene. With 3,579 open tech roles, companies from HCA Healthcare to startup incubators in Midtown and The Block are actively hiring. The city’s business-friendly tax incentives and proximity to the Midwest’s largest transportation hub give tech professionals access to high-paying roles without the high cost of tech-centric coasts.

The region’s tech ecosystem spans healthcare IT, logistics software, fintech, and manufacturing automation. Centene’s data‑science teams, HCA’s cybersecurity engineers, and logistics giants like UPS and FedEx use local talent to power telehealth platforms and supply‑chain analytics. Startups such as Raptor Labs in the Delmar Loop and Kingfisher Labs in Forest Park focus on AI and blockchain, creating a diverse portfolio of opportunities for software engineers, product managers, and DevOps specialists.

Saint Louis offers a moderate cost of living—average rent in Tower Grove or Forest Park is around $1,200–$1,600 per month, and groceries and utilities stay below national averages. Transparent salary information lets candidates evaluate whether a $100,000 software engineering role aligns with their living expenses, especially when considering benefits, relocation packages, and the city’s robust public transportation network.

RN Operating Room

Company: Mercy

Location: Cape Girardeau, Missouri

Posted Dec 22, 2024

Mercy Hospital Southeast is seeking a Full Time RN Operating Room for the Days shift. The job posting does not provide specific details about the role or the hospital environment.

IT Procurement Analyst

Company: Donaldson Company

Location: Minneapolis–Saint Paul, MN

Posted Dec 22, 2024

Donaldson is a company committed to solving complex filtration challenges. They offer a culture of collaboration and innovation, with opportunities in IT procurement, finance, and vendor management. The company values data analysis, business analysis, and strong communication skills. They are committed to equal employment opportunities and comply with export control regulations.

Medical Assistant I/II/III (MAI/II/III)- Ob/Gyn

Company: Kelsey Seybold Clinic

Location: Missouri City, Texas

Posted Dec 22, 2024

Kelsey-Seybold Clinic is offering a full-time Medical Assistant I/II/III position in the Ob/Gyn department at their Sienna location. The role involves providing patient care functions under supervision, ensuring patient safety and comfort. The salary range is $38,422 - $56,413, depending on factors like education, experience, and certifications. Required qualifications include a high school diploma or GED, completion of a Medical Assistant program, and relevant experience. Preferred qualifications include ambulatory care experience and EPIC skills. The clinic offers comprehensive benefits, including medical, vision, dental, tuition reimbursement, a 401K match, and continuing medical education allowance.

Medical Technologist II

Company: Mercy

Location: Saint Louis, Missouri

Posted Dec 22, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer careers that align with individual skills and heart, as recognized by Modern Healthcare Magazine. Benefits include comprehensive health coverage, PTO, tuition reimbursement, and retirement funds. Mercy encourages innovation, collaboration, and going the extra mile to deliver excellent care.

Radiologic Technologist (Non-Exempt) (21012N)

Company: Mercy

Location: Cape Girardeau, Missouri

Posted Dec 22, 2024

Mercy is a healthcare organization that offers a healing ministry through compassionate care and exceptional service. They believe in careers that match unique gifts and talents, and offer great benefits such as comprehensive health coverage and tuition reimbursement. The company values compassion, professionalism, and advocacy, and encourages applicants to join their supportive community.

Physician - Anatomic and Clinical Pathologist - Full Time Academic - SLUCare Physician Group

Company: SSM Health

Location: Saint Louis, Missouri

Posted Dec 23, 2024

SSM Health is seeking an anatomic and clinical pathologist for service at an academic campus. The position includes responsibilities such as anatomic and clinical pathology, teaching pathology residents, and providing excellent service to clinicians. SSM Health has partnered with SLUCare Physician Group for decades to provide exceptional medical services to patients in St. Louis. The city of St. Louis is one of the most livable cities in the country, featuring a large variety of neighborhoods and communities, affordable housing, and a booming economic landscape.

Clinical Supervisor (Non-Exempt) (84030N)

Company: Mercy

Location: Cape Girardeau, Missouri

Posted Dec 22, 2024

Mercy Hospital Southeast is seeking a full-time RN Clinical Supervisor for the night shift. The role involves ensuring high-quality, cost-effective care, efficient resource utilization, and collaboration with administrative personnel and physicians. Benefits include shift differential pay, annual merit increases, tuition reimbursement, comprehensive health benefits, paid parental leave, a 401k with employer match, and opportunities for career growth. Mercy values individual contributions and offers a supportive work environment, recently named one of the 'Top 100 Places to Work' by Modern Healthcare Magazine.

RN - Cardiac Pavilion - Night

Company: Mercy

Location: Cape Girardeau, Missouri

Posted Dec 23, 2024

Mercy Hospital Southeast is offering various incentives for RNs to join their team, including sign-on bonuses, loan forgiveness programs, and tuition reimbursement. They also offer competitive salaries, paid time off, and opportunities for career growth. The company has a strong mission and values compassion, care, and exceptional service.

Application Engineer

Company: ITW

Location: St. Louis, MO

Posted Dec 22, 2024

Diagraph is a leading manufacturer and distributor of inkjet coders, automated labeling systems, thermal transfer inkjet coders, and laser coders. They offer world-class solutions to meet challenging product identification needs and embrace entrepreneurial drive and thinking. The company is a division of ITW, a Fortune 200 global multi-industrial manufacturing leader.

Pharmacy Careers - Missouri - Pharmacist, Pharmacy Technicians

Company: Mercy

Location: Springfield, Missouri

Posted Dec 23, 2024

Mercy is hiring for pharmacy careers, including Clinical Pharmacists, Pharmacy Technicians, and Specialty Pharmacy Account Coordinators. The company is growing and seeking highly qualified talent to support their communities. This is a safety-sensitive position requiring constant alertness and safe work.

Ultrasound Technologist FT Perinatal Lab

Company: Mercy

Location: Saint Louis, Missouri

Posted Dec 22, 2024

Mercy is a top employer offering a range of benefits including comprehensive health coverage, tuition reimbursement, and retirement funds. They value compassionate care and exceptional service, providing careers that align with individual skills and heart. Mercy offers incentives like a Loan Repayment Assistance Program up to $20,000 for Imaging co-workers. The role involves providing diagnostic sonograms and assisting radiologists in procedures. Qualifications include a sonography education, relevant experience, and certifications from ARDMS or ARRT. Mercy is committed to a supportive community, innovation, and community growth.

Physical Therapist (Flex) -Mercy Springfield Acute

Company: Mercy

Location: Springfield, Missouri

Posted Dec 22, 2024

Mercy is seeking a Physical Therapist with a graduate degree, Missouri license, and preferably 1-2 years of experience. The role involves evaluating patients, formulating treatment plans, and providing therapy services. Mercy offers comprehensive benefits including health, vision, dental coverage, PTO, tuition reimbursement, and retirement funds. The company values compassion, professionalism, positive outlook, and advocacy. It provides opportunities for innovation and career growth.

Frequently Asked Questions

What types of tech jobs are available in Saint Louis?
Saint Louis hosts a wide spectrum of tech roles, from software engineers (full‑stack, mobile, backend) and data scientists at Centene to cybersecurity analysts at HCA Healthcare. Product managers, UX designers, and DevOps specialists are in demand at logistics firms like UPS and FedEx, while AI/ML engineers find opportunities at startups such as Raptor Labs and Kingfisher Labs.
Are tech roles in Saint Louis remote, hybrid, or on‑site?
Most senior positions at large employers like HCA and Centene offer hybrid options, allowing employees to work from the downtown office two days a week and remotely the rest. Startups in Midtown and The Block typically require on‑site presence to foster collaboration, but many are expanding their remote talent pool due to the pandemic‑shifted culture.
Who are the major tech employers in Saint Louis?
Key employers include HCA Healthcare’s digital health division, Centene’s analytics teams, UPS and FedEx’s logistics tech hubs, Boeing’s aerospace software labs, and local innovators such as Raptor Labs, Kingfisher Labs, and Innovate St. Louis. The city also attracts national firms like Google and Microsoft through satellite offices.
What salary can I expect for tech roles in Saint Louis?
Software engineers earn between $80,000 and $110,000, with senior positions reaching $120,000+. Data scientists typically earn $90,000–$130,000, while cybersecurity experts command $95,000–$140,000. Benefits packages often include health insurance, retirement plans, and relocation stipends, which can significantly increase total compensation.
How can I relocate to Saint Louis for a tech job?
Start by researching neighborhoods: Tower Grove offers a vibrant student vibe, Delmar Loop offers boutique shopping, and Forest Park provides suburban tranquility. Many employers provide relocation assistance, including housing stipends and moving allowances. Utilize the city’s public transit (MetroLink) and bike lanes to stay connected once you arrive.

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