Tech Jobs in SAINT LOUIS, Missouri

49,974 open positions · Updated daily

Saint Louis has become a magnet for tech talent thanks to its blend of cutting‑edge research, a diverse industrial base, and a network of top universities. Companies from AI leaders like C3.ai to health‑tech innovators such as Slyce and biotech giants like Gilead Sciences are expanding their footprints, creating a steady stream of roles that blend software engineering, data science, and product management.

The city’s tech ecosystem spans several key sectors. In addition to AI and health tech, the region hosts a thriving fintech community with firms such as The Money Store and a growing number of manufacturing‑automation startups. Logistics giants like FedEx and Lumen Technologies maintain large engineering teams, while the University of Missouri‑St. Louis and Washington University drive research collaborations that feed the local talent pool.

With a cost of living about 15 % below the national average, Saint Louis offers a high quality of life without the price tag of coastal hubs. Median home prices hover around $200,000, and the average rent for a one‑bedroom apartment is roughly $1,200. Salary transparency is therefore crucial; it lets candidates compare offers against local living costs and negotiate wages that reflect the true value of their work in a city where money stretches further.

Vascular Surgery - Mosaic Life Care, St. Joseph MO

Company: Mosaic Life Care

Location: Saint Joseph, Missouri

Posted Nov 05, 2024

Mosaic Life Care, a physician-led healthcare system, is seeking a board certified/board eligible Vascular Surgeon. The role involves both inpatient and outpatient services, including minimally invasive techniques, open surgery, dialysis access, and vascular lab interpretation. The surgeon will join a team of two Vascular Surgeons and two APPs, working collaboratively with various specialists. The practice offers a value-based model, competitive salary, and comprehensive benefits. The atmosphere is described as organized, friendly, and energetic, with a 50/50 inpatient/outpatient split and a call rotation of every 3rd day and weekend. Approximately 300-400 cases are handled annually using EPIC EMR. Mosaic Life Care is part of the Mayo Clinic Network and offers additional perks like student loan assistance, extensive insurance coverage, generous time off, professional development support, and relocation assistance.

RN - Med Surg (Days)

Company: Mercy

Location: Aurora, Missouri

Posted Nov 05, 2024

Mercy is offering a Sign On Bonus, PTO Frontload, and Relocation Assistance. They are a Top 100 Places to Work according to Modern Healthcare Magazine. The RN position involves utilizing the nursing process for patient care, maintaining professional accountability, and coordinating care with other departments. Qualifications include a graduate degree from an accredited nursing program, a current RN license, and various certifications. Mercy provides great benefits including health, vision, dental coverage, PTO, tuition reimbursement, and retirement funds. They value compassion, professionalism, a positive outlook, and advocacy in their employees.

Lab Support Tech/Phlebotomist - Full Time Days

Company: Mercy

Location: Saint Louis, Missouri

Posted Nov 04, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer careers that align with individual skills and talents, and have been recognized as a top workplace by Modern Healthcare Magazine. The Laboratory Support Technician (LST II) role involves providing laboratory support, acquiring specimens for testing, and maintaining HIPAA confidentiality. Mercy provides comprehensive benefits including health, vision, dental coverage, PTO, tuition reimbursement, and retirement funds. They encourage applicants who are compassionate, professional, positive, and advocates for excellent care.

Family Medicine | Work with St. Louis University Residents | St. Louis, MO

Company: Jackson Physician Search

Location: Missouri

Posted Nov 04, 2024

An established, award-winning Federally Qualified Health Center in St. Louis, MO is seeking a Primary Care Provider. The organization serves an underserved patient population and offers a 4-day clinic workweek. Benefits include dedicated MA support, integrated specialty support team, and opportunities for procedures. St. Louis, MO offers world-class attractions, top-ranked schools, and easy access to St. Louis Lambert International Airport.

LPN - Oncology Part Time Nights

Company: Mercy

Location: Saint Louis, Missouri

Posted Nov 05, 2024

Mercy Hospital St. Louis is offering a sign-on bonus of up to $3,000 for experienced LPN's. The hospital provides hospital-level experience and tuition assistance for career advancement. The job involves 2-12hr shifts (24 hrs/wk) on nights, with weekend and holiday requirements. Benefits include health/dental/vision, shift differentials, stay pay premium, and free parking. Education assistance programs are available, including a $10,000 scholar loan program for LPN to RN, $20,000 RN-GN nurse loan forgiveness, and $16,000 RN to BSN assistance.

Engineer, Software

Company: Sensei Ag

Location: Minneapolis–Saint Paul, MN

Posted Nov 05, 2024

Sensei Ag is a company that is revolutionizing health and the future of food by merging agriculture and innovation to achieve sustainable farming practices. They are seeking a skilled Software Engineer to enhance their indoor farming technology.

Reg Respiratory Therapist-GIG Springfield

Company: Mercy

Location: Springfield, Missouri

Posted Nov 05, 2024

Mercy Hospital Springfield is offering a flexible Respiratory Therapist (RT) position with a base rate of $35/hr and variable shift incentives. The role involves direct patient care in respiratory care, consulting physicians on therapy effectiveness, and acting as an advanced resource person. Qualifications include a CoArc approved Respiratory Care program graduation, state licensure, RRT credential, and one year of experience. Mercy offers comprehensive benefits, a supportive community, and opportunities for innovation. The company values compassion, professionalism, positive outlook, and advocacy.

Physician - Biochemical Geneticist - Full Time Academic - SLUCare Physician Group

Company: SSM Health

Location: Saint Louis, Missouri

Posted Nov 05, 2024

SSLCare Physician Group, part of SSM Health, is recruiting for a Clinical Biochemical Geneticist position in the Division of Medical Genetics of the Department of Pediatrics. The role is anticipated at the level of Assistant/Associate Professor, with rank and salary based on qualifications and experience. Candidates must have ABMG active candidate status or certification as a Biochemical Geneticist. Responsibilities encompass clinical care, medical education, and administrative tasks. The metabolic team includes physicians, a genetic counselor, nurse, and dietician. The Division offers inpatient and outpatient services at SSM Health Cardinal Glennon Children's Hospital and other sites. It also provides prenatal genetic services in collaboration with the Maternal Fetal Medicine Division. Faculty members engage in clinical and molecular genetics research. Comprehensive diagnostic laboratories are available on-site. Opportunities for teaching at medical student and post-graduate levels are abundant. The ideal candidate should have a passion for academic achievement in clinical genetics. The institution is open to various visa holders, green card holders, and US citizens.

Sr. Process Engineer

Company: Simtra BioPharma Solutions

Location: Minneapolis–Saint Paul, MN

Posted Nov 04, 2024

Simtra BioPharma Solutions is a world-class Contract Development Manufacturing Organization partnering with pharmaceutical and biotech companies to bring their sterile injectable products to market. The company offers a wide range of delivery systems and product types, including biologics and small molecules. The Senior Process Engineer role is responsible for continuous improvement on equipment and processes, and requires a positive attitude, critical thinking, and clear decision-making skills.

General ENT Physician - Saint Luke's - Kansas City, MO

Company: Saint Luke's Health System

Location: Kansas City, Missouri

Posted Nov 05, 2024

Saint Luke’s Health System is recruiting a BC/BE general otolaryngologist for a well-established ENT practice at Saint Luke’s Hospital in Kansas City, MO. The position offers a comprehensive career package, including a guaranteed salary, productivity incentives, and excellent benefits. The hospital, recognized by U.S. News & World Report, provides specialized clinical services and is a primary teaching hospital for UMKC School of Medicine. Kansas City, the home of Saint Luke’s, is known for its affordability, high-quality schools, low traffic, thriving arts scene, and exceptional quality of life.

Radiology Intern II - Paid - Springfield

Company: Mercy

Location: Springfield, Missouri

Posted Nov 05, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer careers that align with individual skills and talents, and have been recognized as a 'Top 100 Places to Work' by Modern Healthcare Magazine. The Radiology Supervisor role involves performing diagnostic radiology procedures under supervision, ensuring optimal image quality, and providing personalized care to patients of all ages. Qualifications include a high school diploma, enrollment in a nationally accredited School of Radiologic Technology, BLS certification, and effective English communication skills. Mercy offers comprehensive benefits, a supportive community, and opportunities for innovation and career growth.

RN - Medical Full Time Days

Company: Mercy

Location: Springfield, Missouri

Posted Nov 05, 2024

The text describes a job offer for a registered nurse with various incentives including a sign-on bonus ranging from $5,000 to $20,000 based on experience, education assistance up to $20,000 for loan forgiveness, tuition reimbursement, and relocation assistance. Additional benefits include comprehensive insurance, retirement funds, and a frontload of up to 80 hours of PTO for experienced RNs. The nurse will work in the 4C unit, serving a medical cardiac population with chronic and acute diseases, requiring physical strength and flexibility.

Frequently Asked Questions

What types of tech jobs are available in Saint Louis?
Saint Louis offers a wide range of tech roles, from Software Engineer and Data Scientist to DevOps Engineer, Product Manager, UI/UX Designer, Cybersecurity Analyst, Mobile Developer, and Cloud Engineer. Companies such as C3.ai, Slyce, Gilead Sciences, FedEx, and Lumen Technologies hire for these positions, as do local fintech startups, manufacturing‑automation firms, and logistics tech teams.
Are tech roles in Saint Louis remote or on-site?
Many tech positions in Saint Louis blend remote and on‑site work. Established firms like Amazon and FedEx offer hybrid schedules, while startups such as Slyce often provide fully remote options. On‑site roles remain common for teams that prioritize collaboration, especially in research labs and manufacturing plants.
Who are the major employers for tech talent in Saint Louis?
Key employers in the region include C3.ai, Slyce, Gilead Sciences, FedEx, Lumen Technologies, Amazon, Google (regional office), the University of Missouri‑St. Louis, Washington University, and St. Louis Children’s Hospital. These organizations drive most of the tech hiring in the city.
What are the salary expectations for tech roles in Saint Louis?
Typical salary ranges in Saint Louis are: Software Engineer $75k–$120k, Senior Software Engineer $100k–$150k, Data Scientist $80k–$130k, Product Manager $90k–$140k, and DevOps Engineer $85k–$130k. The median tech salary hovers around $95k, but exact figures vary by experience, specialization, and company size.
What advice should I follow when relocating to Saint Louis for tech work?
Research local neighborhoods such as Clayton, University City, and Laclede’s Hill for housing and commute options. Leverage salary data on JobTransparency to negotiate competitive offers. Attend local meetups like St. Louis Tech Meetup and C3.ai events to build a network. Consider public transit, bike lanes, and parking when choosing a home. Finally, review relocation packages offered by employers and factor in the city’s lower cost of living to maximize your net income.

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