Tech Jobs in SAINT LOUIS, Missouri

49,974 open positions · Updated daily

Saint Louis has become a magnet for tech talent thanks to its blend of cutting‑edge research, a diverse industrial base, and a network of top universities. Companies from AI leaders like C3.ai to health‑tech innovators such as Slyce and biotech giants like Gilead Sciences are expanding their footprints, creating a steady stream of roles that blend software engineering, data science, and product management.

The city’s tech ecosystem spans several key sectors. In addition to AI and health tech, the region hosts a thriving fintech community with firms such as The Money Store and a growing number of manufacturing‑automation startups. Logistics giants like FedEx and Lumen Technologies maintain large engineering teams, while the University of Missouri‑St. Louis and Washington University drive research collaborations that feed the local talent pool.

With a cost of living about 15 % below the national average, Saint Louis offers a high quality of life without the price tag of coastal hubs. Median home prices hover around $200,000, and the average rent for a one‑bedroom apartment is roughly $1,200. Salary transparency is therefore crucial; it lets candidates compare offers against local living costs and negotiate wages that reflect the true value of their work in a city where money stretches further.

ED Opportunity in Poplar Bluff, MO

Company: Community Health Systems

Location: Poplar Bluff, Missouri 63901

Posted Nov 04, 2024

Poplar Bluff Regional Medical Center, a 250-bed hospital in southeast Missouri, offers a wide range of services including cardiology, orthopedics, general surgery, obstetrics, oncology, nephrology, pulmonary and sleep medicine, wound healing, hyperbarics, and urology. It also has five outreach clinics for family practice services. The hospital is a Level III Trauma Center with 40,000 annual ED volume and 32 ED beds. It provides 36-hour physician and APC coverage with options for W2 employment with full benefits or 1099. The city of Poplar Bluff, with a population of about 17,000, serves as a regional hub for education, healthcare, business, and light industry for over 100,000 people.

RN - Nurse - House Supervisor - Part time (12hrs), Nights

Company: Mercy

Location: Festus, Missouri

Posted Nov 04, 2024

Mercy Hospital Jefferson is a place where nurses can grow and develop their careers. The hospital values its nurses and aims to invest in them, offering supportive care and exceptional service. The role involves assisting in administrative functions, providing EPIC support, and consulting with various hospital staff. Qualifications include a current RN license, at least three years of inpatient hospital experience, and various certifications. Mercy offers great benefits, including comprehensive health coverage, PTO, tuition reimbursement, and retirement funds. The hospital is committed to compassionate care, innovation, and community growth.

New Graduate Nurse Residency -Cardiac Telemetry

Company: Mercy

Location: Washington, Missouri

Posted Nov 04, 2024

Mercy Washington's Cardiac Telemetry Residency is offering a $15,000 sign-on bonus for new graduates. The residency accepts applications now and offers great incentives including education assistance, loan forgiveness, and comprehensive insurance. The unit is high-paced with a 1:4 nurse-to-patient ratio, focusing on cardiac care. Qualifications include a nursing degree, RN license, and relevant certifications.

RN - Float Pool - Mercy Washington

Company: Mercy

Location: Washington, Missouri

Posted Nov 04, 2024

Mercy Hospital Washington is offering a variety of incentives for joining their Float Pool Team. These include sign-on bonuses for experienced and new graduate RNs, relocation assistance, education assistance, loan forgiveness, comprehensive insurance, retirement funds, paid parental leave, tuition reimbursement, and more. The RN will float between the Emergency Department, ICU, Cardiac Telemetry, Medical Surgical, and Medical Surgical- Adults & Peds departments. Qualifications include graduation from an accredited nursing program, a current RN license, and 1 year of RN experience.

Radiologic Technologist III - PRN - Aurora

Company: Mercy

Location: Aurora, Missouri

Posted Nov 04, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer rewarding careers for unique individuals, with benefits including comprehensive health coverage, PTO, tuition reimbursement, and retirement funds. Mercy is committed to innovation, advanced technology, and transforming healthcare. They seek candidates with a positive outlook, strong advocacy, and a collaborative spirit.

Emergency Medicine Physician Is Needed for Locum Tenens Coverage in Missouri CPH# JOB-2996236

Company: CompHealth

Location: Poplar Bluff, Missouri

Posted Nov 04, 2024

CompHealth offers comprehensive support for Emergency Medicine locum tenens in Poplar Bluff, Missouri. Their services include handling credentialing, travel, housing, and negotiating better pay. They provide malpractice coverage, an online portal for assignment details, and a dedicated recruiter for every detail. CompHealth's extensive capabilities and scale ensure they deliver on the details that matter, making them the industry leader in healthcare staffing.

Interventional Radiology Tech | Mercy South

Company: Mercy

Location: Saint Louis, Missouri

Posted Nov 04, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer career opportunities that align with individual skills and heart, as recognized by Modern Healthcare Magazine. Mercy provides incentives like a Loan Repayment Assistance Program up to $20,000 for Imaging co-workers. The role involves working closely with Radiology, OR, Surgeons, and Interventional Radiologists in performing various procedures. Qualifications include a Radiologic Technologist Program graduate with ARRT certification. Mercy offers comprehensive benefits, including health, vision, dental coverage, PTO, tuition reimbursement, and retirement funds. They emphasize a positive work environment, collaboration, and a commitment to excellent care.

RN - Behavioral Health

Company: Mercy

Location: Festus, Missouri

Posted Nov 04, 2024

Mercy Behavioral Health Services offers a structured therapeutic environment for individuals dealing with psychiatric illness, behavioral disorders, and chemical dependency. Their multi-disciplinary team provides evaluation, education, medication therapy, individual and group therapy, and relapse prevention. They also offer attractive benefits including sign-on bonuses, comprehensive insurance, loan forgiveness, tuition reimbursement, shift differentials, paid parental leave, life insurance, 401(k) with employer match, and career growth opportunities.

RN Career Path Program - Stepdown to ICU

Company: Mercy

Location: Springfield, Missouri

Posted Nov 04, 2024

Mercy Springfield is offering a Career Path Program for both new graduates and experienced RNs. The program aims to grow clinical knowledge and skill sets, with benefits including time management, communication, assessment skills, and critical thinking development. Sign-on bonuses, relocation assistance, education assistance, and tuition reimbursement are among the incentives. Mercy Hospital Springfield is recognized for its high-quality care, compassionate team, and commitment to patient safety and innovation.

An Emergency Medicine Physician Is Needed for Locums Help in MO WBY# JOB-2996288

Company: Weatherby Healthcare

Location: Missouri

Posted Nov 04, 2024

Weatherby Healthcare is offering a custom career plan in Emergency Medicine in Missouri. The position requires an active state license (BC or BE), ACLS and PALS certifications, and the ability to handle 40,000 patients per year with Trauma level IV procedures. Benefits include competitive compensation, paid malpractice insurance, pre-paid travel and housing expenses, and 24-hour access to a consultant. Weatherby Healthcare, founded in 1995, is a leading expert in locum tenens staffing for healthcare professionals.

Hospitalist in Birmingham, AL

Company: TeamHealth

Location: 810 Saint Vincents DrBirmingham, Alabama 35205

Posted Nov 04, 2024

St. Vincent Birmingham is expanding its coverage at the flagship facility in downtown Birmingham. This role offers comprehensive support, including 16 hospitalists daily, 2 nocturnists nightly, 24/7 intensivist coverage, and APC support. The position is located in a large referral center with 400 beds, featuring specialty backup, critical care support, and competitive compensation. The hospital is a leader in Robotic Surgery and includes state-of-the-art centers for Cancer, Neuro Spine, Orthopedics, Women's and Children's services, and Cardiac Care. St. Vincent's is a faith-based health system and a member of Ascension Health, the nation's largest Catholic and nonprofit health system.

Dermatopathology Physician

Company: HCA

Location: Kansas City, Missouri 64132

Posted Nov 04, 2024

HCA Healthcare Pathology Services is seeking a board-certified dermatopathologist to join their team at HCA Midwest Health in Kansas City. The successful candidate will be based at the central lab or one of its major hospitals, and must also be able to sign-out general pathology. The role offers competitive salary, comprehensive benefits, and opportunities for career growth. Kansas City, where the position is based, is a thriving metropolis with a high quality of life, numerous job opportunities, and a vibrant food scene.

Frequently Asked Questions

What types of tech jobs are available in Saint Louis?
Saint Louis offers a wide range of tech roles, from Software Engineer and Data Scientist to DevOps Engineer, Product Manager, UI/UX Designer, Cybersecurity Analyst, Mobile Developer, and Cloud Engineer. Companies such as C3.ai, Slyce, Gilead Sciences, FedEx, and Lumen Technologies hire for these positions, as do local fintech startups, manufacturing‑automation firms, and logistics tech teams.
Are tech roles in Saint Louis remote or on-site?
Many tech positions in Saint Louis blend remote and on‑site work. Established firms like Amazon and FedEx offer hybrid schedules, while startups such as Slyce often provide fully remote options. On‑site roles remain common for teams that prioritize collaboration, especially in research labs and manufacturing plants.
Who are the major employers for tech talent in Saint Louis?
Key employers in the region include C3.ai, Slyce, Gilead Sciences, FedEx, Lumen Technologies, Amazon, Google (regional office), the University of Missouri‑St. Louis, Washington University, and St. Louis Children’s Hospital. These organizations drive most of the tech hiring in the city.
What are the salary expectations for tech roles in Saint Louis?
Typical salary ranges in Saint Louis are: Software Engineer $75k–$120k, Senior Software Engineer $100k–$150k, Data Scientist $80k–$130k, Product Manager $90k–$140k, and DevOps Engineer $85k–$130k. The median tech salary hovers around $95k, but exact figures vary by experience, specialization, and company size.
What advice should I follow when relocating to Saint Louis for tech work?
Research local neighborhoods such as Clayton, University City, and Laclede’s Hill for housing and commute options. Leverage salary data on JobTransparency to negotiate competitive offers. Attend local meetups like St. Louis Tech Meetup and C3.ai events to build a network. Consider public transit, bike lanes, and parking when choosing a home. Finally, review relocation packages offered by employers and factor in the city’s lower cost of living to maximize your net income.

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