Tech Jobs in SAINT LOUIS, Missouri

49,974 open positions · Updated daily

Saint Louis has become a magnet for tech talent thanks to its blend of cutting‑edge research, a diverse industrial base, and a network of top universities. Companies from AI leaders like C3.ai to health‑tech innovators such as Slyce and biotech giants like Gilead Sciences are expanding their footprints, creating a steady stream of roles that blend software engineering, data science, and product management.

The city’s tech ecosystem spans several key sectors. In addition to AI and health tech, the region hosts a thriving fintech community with firms such as The Money Store and a growing number of manufacturing‑automation startups. Logistics giants like FedEx and Lumen Technologies maintain large engineering teams, while the University of Missouri‑St. Louis and Washington University drive research collaborations that feed the local talent pool.

With a cost of living about 15 % below the national average, Saint Louis offers a high quality of life without the price tag of coastal hubs. Median home prices hover around $200,000, and the average rent for a one‑bedroom apartment is roughly $1,200. Salary transparency is therefore crucial; it lets candidates compare offers against local living costs and negotiate wages that reflect the true value of their work in a city where money stretches further.

PHYSICIAN ASSISTANT (ORTHOPEDICS)

Company: Department of Veterans Affairs - Veterans Health Administration

Location: Saint Louis, Missouri Saint Louis, Missouri

Posted Sep 30, 2024

The Physician Assistant PA position is located within the VA St Louis Health Care System VASTLHCS Surgery Service with a specialty of Orthopedics. The PA is a professional who executes position responsibilities that demonstrates leadership experience and creative approaches to the management of complex client care.

RN - Obstetrics (PRN Varies)

Company: Mercy

Location: Aurora, Missouri

Posted Sep 30, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer competitive benefits, including comprehensive health coverage, PTO, tuition reimbursement, and retirement funds. Mercy is committed to providing careers that align with individual skills and hearts, and they encourage collaboration and going above and beyond to deliver excellent care. They are currently seeking a Registered Nurse with relevant certifications for an Obstetrics position in Labor & Delivery.

Urban Agricultural County Program Analyst

Company: Department of Agriculture - Farm Service Agency

Location: Saint Matthews, South Carolina Saint Matthews, South Carolina

Posted Sep 30, 2024

This is an Urban Agricultural County Program Analyst position with responsibilities including serving as an expert in various areas.

Urology Physician - Beautiful Lake of the Ozarks - Osage Beach, Missouri

Company: Inspire Healthcare

Location: Osage Beach, Missouri

Posted Sep 30, 2024

This job posting is for a BC/BE urologist physician to join an established practice in Osage Beach, Missouri. The position offers a supportive culture, competitive salary, comprehensive benefits, and a sign-on bonus. The location provides a strong school district, big city amenities in a small town setting, and easy access to nature and lakes. Inspire Healthcare, the company offering the position, emphasizes personal relationships and customer service.

Practical Nurse

Company: Department of Veterans Affairs - Veterans Health Administration

Location: Manchester, Missouri Manchester, Missouri

Posted Sep 30, 2024

The LPN is expected to exercise technical judgment independently and requires minimal or no guidance and direction. Completed work generally needs little review by a registered nurse for technical soundness, appropriateness, and conformity to policy and accepted nursing standards.

Illinois Urology Job - Loan Forgiveness and More Included

Company: Curare Physician Recruiting

Location: St. Louis, Missouri 63101

Posted Sep 30, 2024

A urology opportunity is available in southern Illinois, specifically in St. Louis, Missouri. The organization is a financially strong, forward-thinking, and the largest provider of charity care in the area. They offer a generous compensation package, full benefits, and a modern surgical center with Da Vinci Xi. The community is friendly, diverse, and surrounded by state parks and national forests, offering recreational activities and quality schools. The Curare Group, a key player in the physician recruitment industry for 25 years, is facilitating this opportunity, providing support from CV writing to contract negotiation.

ATTORNEY-ADVISOR (GENERAL)

Company: Department of the Air Force - Air Force Global Strike Command

Location: Whiteman AFB, Missouri Whiteman AFB, Missouri

Posted Sep 30, 2024

The position is to support the Staff Judge Advocate SJA as a senior attorney providing legal advice and counsel for complex cases in various laws to the 509th Bomb Wing and tenant units.

Reg Respiratory Therapist -Mercy Joplin-PRN

Company: Mercy

Location: Joplin, Missouri

Posted Sep 30, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer careers that align with individual skills and hearts, and have been recognized as a top workplace. The Respiratory Care position involves direct patient care, consulting with physicians, and acting as an advanced resource person. Qualifications include a CoArc approved Respiratory Care program graduation, state licensure, RRT credential, and preferred experience in critical care. Mercy provides great benefits including health, vision, dental coverage, PTO, tuition reimbursement, and retirement funds. They are committed to innovation, collaboration, and delivering excellent care.

Urology Opening in MO

Company: Archway Physician Recruitment

Location: Poplar Bluff, Missouri

Posted Sep 30, 2024

A urology position is available in Poplar Bluff, MO, a family-friendly community with a low cost of living. The position offers a competitive recruitment package, including base salary, full benefits, relocation assistance, and potential bonuses. The community boasts access to rivers for outdoor activities, a strong public school system, and a golf course. The practice is equipped with 2 Da Vinci robots and urodynamics, with a call schedule of 1:2.

Physical Therapy Assistant -Mercy Hospital Cassville-Full Time

Company: Mercy

Location: Cassville, Missouri

Posted Sep 30, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer careers that align with individual skills and heart, and have been recognized as a top workplace. The Physical Therapist Assistant position involves administering therapeutic modalities and assisting with medical records and department maintenance. Mercy provides comprehensive benefits, including health, vision, and dental coverage, PTO, tuition reimbursement, and retirement funds. They encourage applicants who are compassionate, professional, positive, and advocates for excellent care.

No Call in this Group-Employed Uro-Gynecology Job in Saint Paul, MN

Company: Curare Physician Recruiting

Location: Saint Paul, Minnesota 55109

Posted Sep 30, 2024

A fellowship-trained Urogynecologist is sought by an established single-specialty group in Saint Paul, Minnesota. The opportunity offers an earning potential of $600k, no call, and additional benefits such as WRVU production incentives, CME time, and $4,000. The group uses eClinicalWorks for EMR and there's potential for ancillary income from a Surgery Center. The Curare Group, a physician recruitment industry leader for 25 years, supports the job search process.

Pharmacy Student - PRN (As Needed)

Company: Mercy

Location: Creve Coeur, Missouri

Posted Sep 30, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer careers that align with individual skills and hearts, and have been recognized as a top workplace. The role of a Pharmacy Technician involves supporting the Pharmacist in medication preparation, distribution, and inventory control. Mercy provides great benefits including health, vision, and dental coverage, PTO, tuition reimbursement, and retirement funds. They encourage applicants who are compassionate, professional, positive, and advocates for excellent care.

Frequently Asked Questions

What types of tech jobs are available in Saint Louis?
Saint Louis offers a wide range of tech roles, from Software Engineer and Data Scientist to DevOps Engineer, Product Manager, UI/UX Designer, Cybersecurity Analyst, Mobile Developer, and Cloud Engineer. Companies such as C3.ai, Slyce, Gilead Sciences, FedEx, and Lumen Technologies hire for these positions, as do local fintech startups, manufacturing‑automation firms, and logistics tech teams.
Are tech roles in Saint Louis remote or on-site?
Many tech positions in Saint Louis blend remote and on‑site work. Established firms like Amazon and FedEx offer hybrid schedules, while startups such as Slyce often provide fully remote options. On‑site roles remain common for teams that prioritize collaboration, especially in research labs and manufacturing plants.
Who are the major employers for tech talent in Saint Louis?
Key employers in the region include C3.ai, Slyce, Gilead Sciences, FedEx, Lumen Technologies, Amazon, Google (regional office), the University of Missouri‑St. Louis, Washington University, and St. Louis Children’s Hospital. These organizations drive most of the tech hiring in the city.
What are the salary expectations for tech roles in Saint Louis?
Typical salary ranges in Saint Louis are: Software Engineer $75k–$120k, Senior Software Engineer $100k–$150k, Data Scientist $80k–$130k, Product Manager $90k–$140k, and DevOps Engineer $85k–$130k. The median tech salary hovers around $95k, but exact figures vary by experience, specialization, and company size.
What advice should I follow when relocating to Saint Louis for tech work?
Research local neighborhoods such as Clayton, University City, and Laclede’s Hill for housing and commute options. Leverage salary data on JobTransparency to negotiate competitive offers. Attend local meetups like St. Louis Tech Meetup and C3.ai events to build a network. Consider public transit, bike lanes, and parking when choosing a home. Finally, review relocation packages offered by employers and factor in the city’s lower cost of living to maximize your net income.

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