Tech Jobs in SAINT LOUIS, Missouri

49,974 open positions · Updated daily

Saint Louis has become a magnet for tech talent thanks to its blend of cutting‑edge research, a diverse industrial base, and a network of top universities. Companies from AI leaders like C3.ai to health‑tech innovators such as Slyce and biotech giants like Gilead Sciences are expanding their footprints, creating a steady stream of roles that blend software engineering, data science, and product management.

The city’s tech ecosystem spans several key sectors. In addition to AI and health tech, the region hosts a thriving fintech community with firms such as The Money Store and a growing number of manufacturing‑automation startups. Logistics giants like FedEx and Lumen Technologies maintain large engineering teams, while the University of Missouri‑St. Louis and Washington University drive research collaborations that feed the local talent pool.

With a cost of living about 15 % below the national average, Saint Louis offers a high quality of life without the price tag of coastal hubs. Median home prices hover around $200,000, and the average rent for a one‑bedroom apartment is roughly $1,200. Salary transparency is therefore crucial; it lets candidates compare offers against local living costs and negotiate wages that reflect the true value of their work in a city where money stretches further.

GASTROENTEROLOGIST

Company: University Health Physicians

Location: Kansas City, Missouri

Posted Sep 30, 2024

University Health Physicians (UHP) is a multi-specialty academic group practice affiliated with the University of Missouri – Kansas City School of Medicine (UMKC SOM). UHP is a 501(c)(3) not-for-profit and an equal opportunity employer. UHP physicians have teaching responsibilities for residents, fellows, and medical students. UH, known as 'Kansas City's Essential Hospital', is an academic medical center serving as the primary teaching institution for UMKC Schools of Medicine, Nursing, Dentistry, and Pharmacy. UH is recognized for its high-quality medical care, compassion, and dedication to service, especially during the 2020 pandemic. The position requires completion of a Gastroenterology Fellowship and a Missouri Medical License. Benefits include a comprehensive salary, retirement plan, professional liability insurance, Paid Time Off, and CME reimbursements.

LPN - Home Health, Part Time

Company: Mercy

Location: Des Peres, Missouri

Posted Sep 30, 2024

Mercy Home Health is a highly-rated agency offering a range of benefits to its staff. They provide autonomous care to patients in their homes, catering to diverse social backgrounds, cultures, age groups, and social dynamics. The company offers a sign-on bonus for experienced LPN's, gas mileage reimbursement, benefits and PTO accrual from day one, tuition reimbursement, and a comprehensive medical, dental, and vision insurance plan. They also provide flexible scheduling, family-friendly policies, paid parental leave, life insurance, a 401(k) with employer match, and opportunities for career growth. The LPN role involves providing skilled nursing services to patients under the supervision of a registered nurse, assessing, planning, implementing, and evaluating patients' needs and care.

IT SPECIALIST (NETWORK) (TITLE 5)

Company: Department of the Army - Army National Guard Units

Location: Jefferson City, Missouri Jefferson City, Missouri

Posted Sep 30, 2024

This is a National Guard Title 5 Excepted Service Position. It is a nonbargaining position.

Transportation Program Specialist - DIRECT HIRE (BIL)

Company: Department of Transportation - Federal Transit Administration

Location: Kansas City, Missouri Kansas City, Missouri

Posted Sep 30, 2024

FTA authorized positions open to US Citizens for Transportation Data Analyst and Transportation Program Specialist roles.

RN - Medical Stepdown - Days

Company: Mercy

Location: Sappington, Missouri

Posted Sep 30, 2024

Mercy South Medical Stepdown is seeking experienced and graduate nurses for a unit specializing in acutely ill medical patients, particularly those with respiratory issues. The unit offers a residency program, sign-on bonuses, relocation assistance, and no contracts. The RN ratio is 3-4 patients with tech support, and there is 24/7 leadership support. The role requires excellent critical thinking and decision-making skills, a close relationship with pulmonologists, and collaboration with various teams. Mercy offers great benefits, including health, vision, and dental coverage, PTO, tuition reimbursement, and employer-matched retirement funds.

Transitional Teacher (MS English-Language Arts/Social Studies)

Company: Department of the Interior - Bureau of Indian Education

Location: Saint Stephens, Wyoming Saint Stephens, Wyoming

Posted Sep 30, 2024

This position is part of the St Stephens Indian School Bureau of Indian Education. As a Transitional Teacher, you will be responsible for serving as a classroom teacher in a BIE school on or near the Reservation.

Assistant United States Attorney (Criminal)

Company: Department of Justice - Executive Office for U.S. Attorneys and the Office of the U.S. Attorneys

Location: Saint Thomas, Virgin Islands Saint Thomas, Virgin Islands

Posted Sep 30, 2024

The United States Attorneys Office is seeking an experienced attorney with outstanding prosecution research and writing skills. The position is located in Saint Thomas, United States Virgin Islands.

Assistant United States Attorney (Criminal)

Company: Department of Justice - Executive Office for U.S. Attorneys and the Office of the U.S. Attorneys

Location: Saint Croix, Virgin Islands Saint Croix, Virgin Islands

Posted Sep 30, 2024

The United States Attorneys Office is seeking an experienced attorney with outstanding prosecution research and writing skills. The position is located in Saint Croix, United States Virgin Islands.

Budget Analyst

Company: Department of the Army - U.S. Army Corps of Engineers

Location: Kansas City, Missouri Kansas City, Missouri

Posted Sep 30, 2024

The job posting is for a Budget Analyst position in the Kansas City District Construction Division, involving budget formulation, justification, and execution.

Teacher (MS English-Language Arts/Social Studies)

Company: Department of the Interior - Bureau of Indian Education

Location: Saint Stephens, Wyoming Saint Stephens, Wyoming

Posted Sep 30, 2024

This position is part of the St Stephens Indian School Bureau of Indian Education. As a Teacher, you will be responsible for serving as a classroom teacher in a BIE school on or near the Reservation.

LPN- Part Time Med/ Surg, Nights

Company: Mercy

Location: Sappington, Missouri

Posted Sep 30, 2024

The job posting is for a Licensed Practical Nurse (LPN) position, offering attractive incentives such as a $5,000 sign-on bonus for new graduates and $7,500 for experienced LPNs. The role involves providing individualized nursing care under the supervision of a Registered Nurse, with a proposed schedule of 12-hour shifts. The position offers comprehensive benefits, including health, vision, and dental coverage, PTO, tuition reimbursement, and employer-matched retirement funds. The job requires a graduate of an accredited practical nursing program, a current LPN license, and Basic Life Support certification.

Nurse (Clinical/Psychiatric)

Company: Department of Defense - Military Treatment Facilities under DHA

Location: Fort Leonard Wood, Missouri Fort Leonard Wood, Missouri

Posted Sep 30, 2024

This job posting is for a position at Army Community Hospital Fort Leonard Wood Missouri. It is a direct hire solicitation with potential for salary negotiation for new federal employees.

Frequently Asked Questions

What types of tech jobs are available in Saint Louis?
Saint Louis offers a wide range of tech roles, from Software Engineer and Data Scientist to DevOps Engineer, Product Manager, UI/UX Designer, Cybersecurity Analyst, Mobile Developer, and Cloud Engineer. Companies such as C3.ai, Slyce, Gilead Sciences, FedEx, and Lumen Technologies hire for these positions, as do local fintech startups, manufacturing‑automation firms, and logistics tech teams.
Are tech roles in Saint Louis remote or on-site?
Many tech positions in Saint Louis blend remote and on‑site work. Established firms like Amazon and FedEx offer hybrid schedules, while startups such as Slyce often provide fully remote options. On‑site roles remain common for teams that prioritize collaboration, especially in research labs and manufacturing plants.
Who are the major employers for tech talent in Saint Louis?
Key employers in the region include C3.ai, Slyce, Gilead Sciences, FedEx, Lumen Technologies, Amazon, Google (regional office), the University of Missouri‑St. Louis, Washington University, and St. Louis Children’s Hospital. These organizations drive most of the tech hiring in the city.
What are the salary expectations for tech roles in Saint Louis?
Typical salary ranges in Saint Louis are: Software Engineer $75k–$120k, Senior Software Engineer $100k–$150k, Data Scientist $80k–$130k, Product Manager $90k–$140k, and DevOps Engineer $85k–$130k. The median tech salary hovers around $95k, but exact figures vary by experience, specialization, and company size.
What advice should I follow when relocating to Saint Louis for tech work?
Research local neighborhoods such as Clayton, University City, and Laclede’s Hill for housing and commute options. Leverage salary data on JobTransparency to negotiate competitive offers. Attend local meetups like St. Louis Tech Meetup and C3.ai events to build a network. Consider public transit, bike lanes, and parking when choosing a home. Finally, review relocation packages offered by employers and factor in the city’s lower cost of living to maximize your net income.

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