Tech Jobs in SAINT LOUIS, Missouri

49,974 open positions · Updated daily

Saint Louis has become a magnet for tech talent thanks to its blend of cutting‑edge research, a diverse industrial base, and a network of top universities. Companies from AI leaders like C3.ai to health‑tech innovators such as Slyce and biotech giants like Gilead Sciences are expanding their footprints, creating a steady stream of roles that blend software engineering, data science, and product management.

The city’s tech ecosystem spans several key sectors. In addition to AI and health tech, the region hosts a thriving fintech community with firms such as The Money Store and a growing number of manufacturing‑automation startups. Logistics giants like FedEx and Lumen Technologies maintain large engineering teams, while the University of Missouri‑St. Louis and Washington University drive research collaborations that feed the local talent pool.

With a cost of living about 15 % below the national average, Saint Louis offers a high quality of life without the price tag of coastal hubs. Median home prices hover around $200,000, and the average rent for a one‑bedroom apartment is roughly $1,200. Salary transparency is therefore crucial; it lets candidates compare offers against local living costs and negotiate wages that reflect the true value of their work in a city where money stretches further.

Designer/Drafter

Company: ITW

Location: Minneapolis–Saint Paul, MN

Posted Sep 30, 2024

The job description highlights the company's commitment to innovation, growth, and employee development. The company is looking for a team-oriented individual who is eager to learn and grow in their design career. The job involves creating precise design documentation, supporting the manufacture and sale of products, and collaborating with internal and external teams.

Account Executive - Expansion Sales

Company: HighRadius

Location: Minneapolis–Saint Paul, MN

Posted Sep 30, 2024

HighRadius is looking for an Account Executive to join their Expansion Sales team. The role involves helping CFOs and finance leaders transform their finance landscape through cutting-edge technology. The ideal candidate has experience in SaaS, financial processes, and stakeholder management, and is results-driven and resilient.

Archives Technician

Company: Other Agencies and Independent Organizations - National Archives and Records Administration

Location: Independence, Missouri Independence, Missouri

Posted Sep 30, 2024

The position is part of the National Archives and Records Administration, performing work that supports access to archival holdings and physical and intellectual control over records.

General Manager

Company: Department of Veterans Affairs - Veterans Health Administration

Location: Kansas City, Missouri Kansas City, Missouri

Posted Sep 30, 2024

The Veterans Canteen Service is seeking dynamic General Managers to join their fast-paced environment and serve Veterans and their families.

Physical Science Technician

Company: Department of the Interior - Geological Survey

Location: Columbia, Missouri Columbia, Missouri

Posted Sep 30, 2024

This is a term appointment for 13 months with possible extensions up to 4 years. It does not convey permanent status in the Federal service. The salary is $39,578 to $51,446.

RN - Cardiac Medical ICU / Cardiac Vascular ICU - Nights

Company: Mercy

Location: Sappington, Missouri

Posted Sep 30, 2024

Mercy is offering a graduate and experienced nurse position in their 22-bed Cardiac Medical Intensive Care Unit (CMICU). The unit specializes in treating patients with organ system failure, post-cardiac arrest, life-threatening arrhythmias, sepsis, diabetic ketoacidosis, GI bleed, overdose, Covid, mental health/self-harm, paralytics/prone therapy, and continuous renal replacement therapy. The unit provides advanced cardiovascular training, designated rooms for CVICU patients, and specially trained CVICU RNs for recovering open hearts and transcatheter aortic and mitral valve repairs/replacements. The nurse/patient ratio is 1:2, with 1:1 for acuity. Mercy offers great benefits including day-one comprehensive health, vision, and dental coverage, PTO, tuition reimbursement, and employer-matched retirement funds.

Biologist

Company: Department of the Interior - Geological Survey

Location: Columbia, Missouri Columbia, Missouri

Posted Sep 30, 2024

This is a term appointment for 13 months with possible extensions up to 4 years. It does not convey permanent status in the Federal service. The salary is $49,025 to $77,955.

RN - Rehab Hospital (Nights)

Company: Mercy

Location: Springfield, Missouri

Posted Sep 30, 2024

Mercy is offering a Sign On Bonus, PTO Frontload, and Relocation Assistance. They are a Top 100 Places to Work according to Modern Healthcare Magazine. The RN position involves utilizing the nursing process to provide patient care, maintaining professional accountability, and coordinating patient care with other departments. Mercy values compassion, professionalism, and a positive outlook. They offer great benefits including day-one comprehensive health, vision, and dental coverage, PTO, tuition reimbursement, and employer-matched retirement funds.

Nurse (Specialty Clinic Coordinator)

Company: Department of Justice - Justice, Bureau of Prisons/Federal Prison System

Location: Springfield, Missouri Springfield, Missouri

Posted Sep 30, 2024

The agency fosters a humane and secure environment, ensuring public safety and preparing individuals for successful reentry into their communities. Their diverse and innovative workforce creates a strong foundation of safety and security through principles of humanity and normalcy.

Human Resources Specialist

Company: Department of Homeland Security - Transportation Security Administration

Location: Bridgeton, Missouri Bridgeton, Missouri

Posted Sep 30, 2024

The Transportation Security Administration secures airports, seaports, and other transportation systems to protect the American way of life and ensure freedom of movement.

Radiologic Technologist Full-time Days

Company: Mercy

Location: Festus, Missouri

Posted Sep 30, 2024

Mercy is a healthcare organization that values compassionate care and exceptional service. They offer competitive benefits, including loan repayment assistance and sign-on bonuses. The role involves assisting radiologists in performing interventional and special procedures, and providing patient care. Qualifications include a successful completion of an accredited Radiography program, relevant experience, and A.R.R.T. registration. Mercy is committed to fostering a supportive community and offers opportunities for professional growth and innovation in healthcare.

Gastroenterologist

Company: Department of Veterans Affairs

Location: Poplar Bluff, Missouri

Posted Sep 30, 2024

The John J. Pershing VA Medical Center in Poplar Bluff, MO is recruiting a full-time Gastroenterologist. The role involves treating, diagnosing, and managing patients with GI disorders, including liver disease, Hepatitis C, and liver transplants. The work schedule is Monday-Friday, 8:00am - 4:30 pm with no call duties. The average case load is 6-8 procedures a day and 10-12 clinic patients. The facility offers a competitive salary of $350K - $400K, annual performance bonus, and comprehensive benefits including health insurance, dental, vision, retirement plans, and more. Poplar Bluff is known as 'The Gateway to the Ozarks' and offers various attractions, shopping, and recreational activities.

Frequently Asked Questions

What types of tech jobs are available in Saint Louis?
Saint Louis offers a wide range of tech roles, from Software Engineer and Data Scientist to DevOps Engineer, Product Manager, UI/UX Designer, Cybersecurity Analyst, Mobile Developer, and Cloud Engineer. Companies such as C3.ai, Slyce, Gilead Sciences, FedEx, and Lumen Technologies hire for these positions, as do local fintech startups, manufacturing‑automation firms, and logistics tech teams.
Are tech roles in Saint Louis remote or on-site?
Many tech positions in Saint Louis blend remote and on‑site work. Established firms like Amazon and FedEx offer hybrid schedules, while startups such as Slyce often provide fully remote options. On‑site roles remain common for teams that prioritize collaboration, especially in research labs and manufacturing plants.
Who are the major employers for tech talent in Saint Louis?
Key employers in the region include C3.ai, Slyce, Gilead Sciences, FedEx, Lumen Technologies, Amazon, Google (regional office), the University of Missouri‑St. Louis, Washington University, and St. Louis Children’s Hospital. These organizations drive most of the tech hiring in the city.
What are the salary expectations for tech roles in Saint Louis?
Typical salary ranges in Saint Louis are: Software Engineer $75k–$120k, Senior Software Engineer $100k–$150k, Data Scientist $80k–$130k, Product Manager $90k–$140k, and DevOps Engineer $85k–$130k. The median tech salary hovers around $95k, but exact figures vary by experience, specialization, and company size.
What advice should I follow when relocating to Saint Louis for tech work?
Research local neighborhoods such as Clayton, University City, and Laclede’s Hill for housing and commute options. Leverage salary data on JobTransparency to negotiate competitive offers. Attend local meetups like St. Louis Tech Meetup and C3.ai events to build a network. Consider public transit, bike lanes, and parking when choosing a home. Finally, review relocation packages offered by employers and factor in the city’s lower cost of living to maximize your net income.

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